Gene description for CLCA4
Gene name chloride channel accessory 4
Gene symbol CLCA4
Other names/aliases CaCC
CaCC2
Species Homo sapiens
 Database cross references - CLCA4
ExoCarta ExoCarta_22802
Vesiclepedia VP_22802
Entrez Gene 22802
HGNC 2018
UniProt Q14CN2  
 CLCA4 identified in sEVs derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for CLCA4
Molecular Function
    metalloendopeptidase activity GO:0004222 TAS
    intracellularly calcium-gated chloride channel activity GO:0005229 IBA
    chloride channel activity GO:0005254 TAS
    metal ion binding GO:0046872 IEA
Biological Process
    proteolysis GO:0006508 IEA
    monoatomic ion transmembrane transport GO:0034220 TAS
    chloride transmembrane transport GO:1902476 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified CLCA4 in sEVs
1
Experiment ID 66
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for CLCA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BDKRB2  
Two-hybrid Homo sapiens
2 SRRT 51593
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CLCA4 is involved
PathwayEvidenceSource
Ion channel transport TAS Reactome
Stimuli-sensing channels TAS Reactome
Transport of small molecules TAS Reactome





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