Gene description for CLCA4
Gene name chloride channel accessory 4
Gene symbol CLCA4
Other names/aliases CaCC
CaCC2
Species Homo sapiens
 Database cross references - CLCA4
ExoCarta ExoCarta_22802
Vesiclepedia VP_22802
Entrez Gene 22802
HGNC 2018
UniProt Q14CN2  
 CLCA4 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for CLCA4
Molecular Function
    metallopeptidase activity GO:0008237 IEA
    intracellular calcium activated chloride channel activity GO:0005229 IBA
    metal ion binding GO:0046872 IEA
    chloride channel activity GO:0005254 TAS
Biological Process
    chloride transport GO:0006821 TAS
    proteolysis GO:0006508 IEA
    ion transmembrane transport GO:0034220 TAS
    chloride transmembrane transport GO:1902476 TAS
    transmembrane transport GO:0055085 TAS
    transport GO:0006810 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
    extracellular exosome GO:0070062 IDA
    apical plasma membrane GO:0016324 IEA
 Experiment description of studies that identified CLCA4 in exosomes
1
Experiment ID 66
MISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix|CD63|CD81
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for CLCA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CLCA4 is involved
PathwayEvidenceSource
Stimuli-sensing channels TAS Reactome





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