Gene description for NLGN4Y
Gene name neuroligin 4, Y-linked
Gene symbol NLGN4Y
Other names/aliases -
Species Homo sapiens
 Database cross references - NLGN4Y
ExoCarta ExoCarta_22829
Vesiclepedia VP_22829
Entrez Gene 22829
HGNC 15529
MIM 400028
UniProt Q8NFZ3  
 NLGN4Y identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for NLGN4Y
Molecular Function
    protein binding GO:0005515 IPI
    cell adhesion molecule binding GO:0050839 TAS
    scaffold protein binding GO:0097110 IPI
Biological Process
    neuron cell-cell adhesion GO:0007158 TAS
    learning GO:0007612 IMP
    social behavior GO:0035176 IMP
    vocalization behavior GO:0071625 IMP
    presynapse assembly GO:0099054 TAS
Subcellular Localization
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
    presynapse GO:0098793 IEA
    postsynaptic density membrane GO:0098839 IEA
    symmetric, GABA-ergic, inhibitory synapse GO:0098983 TAS
    asymmetric, glutamatergic, excitatory synapse GO:0098985 TAS
    postsynaptic specialization membrane GO:0099634 IBA
 Experiment description of studies that identified NLGN4Y in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for NLGN4Y
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBB 7314
Affinity Capture-MS Homo sapiens
2 PRIM2 5558
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 NLGN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PRIM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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