Gene description for Osbpl2
Gene name oxysterol binding protein-like 2
Gene symbol Osbpl2
Other names/aliases C130070J12Rik
ORP-2
Orp2
mKIAA0772
Species Mus musculus
 Database cross references - Osbpl2
ExoCarta ExoCarta_228983
Vesiclepedia VP_228983
Entrez Gene 228983
UniProt Q8BX94  
 Osbpl2 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Osbpl2
Molecular Function
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISO
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISS
    phosphatidylinositol transfer activity GO:0008526 ISO
    phosphatidylinositol transfer activity GO:0008526 ISS
    cholesterol binding GO:0015485 IBA
    cholesterol binding GO:0015485 IEA
    cholesterol binding GO:0015485 ISO
    cholesterol transfer activity GO:0120020 ISO
    cholesterol transfer activity GO:0120020 ISS
Biological Process
    plasma membrane organization GO:0007009 IEA
    plasma membrane organization GO:0007009 ISO
    regulation of synaptic vesicle priming GO:0010807 IEA
    regulation of synaptic vesicle priming GO:0010807 ISO
    phospholipid transport GO:0015914 IEA
    phospholipid transport GO:0015914 ISO
    cholesterol transport GO:0030301 ISO
    intracellular cholesterol transport GO:0032367 ISO
    intracellular cholesterol transport GO:0032367 ISS
    protein homotetramerization GO:0051289 ISO
    protein homotetramerization GO:0051289 ISS
    regulation of presynaptic cytosolic calcium ion concentration GO:0099509 IDA
    intermembrane lipid transfer GO:0120009 IEA
Subcellular Localization
    lipid droplet GO:0005811 ISO
    lipid droplet GO:0005811 ISS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 IBA
    cytoplasmic side of plasma membrane GO:0009898 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISS
    perinuclear endoplasmic reticulum GO:0097038 IBA
    presynaptic active zone cytoplasmic component GO:0098831 IDA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Osbpl2 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Osbpl2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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