Gene description for Gbp7
Gene name guanylate binding protein 7
Gene symbol Gbp7
Other names/aliases 9830147J24Rik
Species Mus musculus
 Database cross references - Gbp7
ExoCarta ExoCarta_229900
Vesiclepedia VP_229900
Entrez Gene 229900
 Gbp7 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Gbp7
Molecular Function
    GTPase activity GO:0003924 IBA
    GTPase activity GO:0003924 IMP
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IBA
    GTP binding GO:0005525 IMP
Biological Process
    negative regulation of cytokine production GO:0001818 ISO
    negative regulation of cytokine production GO:0001818 ISS
    activation of innate immune response GO:0002218 IMP
    negative regulation of type I interferon production GO:0032480 ISO
    negative regulation of type I interferon production GO:0032480 ISS
    negative regulation of type III interferon production GO:0034345 ISO
    negative regulation of type III interferon production GO:0034345 ISS
    cellular response to interferon-beta GO:0035458 IDA
    defense response to bacterium GO:0042742 IMP
    defense response to protozoan GO:0042832 IBA
    defense response to protozoan GO:0042832 IDA
    defense response to protozoan GO:0042832 IMP
    defense response to protozoan GO:0042832 IMP
    regulation of canonical NF-kappaB signal transduction GO:0043122 ISO
    regulation of canonical NF-kappaB signal transduction GO:0043122 ISS
    adhesion of symbiont to host GO:0044406 IDA
    positive regulation of viral genome replication GO:0045070 ISO
    positive regulation of viral genome replication GO:0045070 ISS
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 ISO
    negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 ISS
    defense response to Gram-positive bacterium GO:0050830 IBA
    defense response to Gram-positive bacterium GO:0050830 IDA
    defense response to virus GO:0051607 IDA
    defense response to virus GO:0051607 ISO
    cytolysis in another organism GO:0051715 IMP
    cellular response to type II interferon GO:0071346 IBA
    cellular response to type II interferon GO:0071346 IDA
Subcellular Localization
    symbiont-containing vacuole membrane GO:0020005 IDA
    cytoplasmic vesicle membrane GO:0030659 IEA
    cytoplasmic vesicle GO:0031410 IBA
    cytoplasmic vesicle GO:0031410 IDA
 Experiment description of studies that identified Gbp7 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Gbp7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gbp7 is involved
No pathways found





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