Gene description for Car9
Gene name carbonic anhydrase 9
Gene symbol Car9
Other names/aliases CAIX
Ca9
MN/CA9
Species Mus musculus
 Database cross references - Car9
ExoCarta ExoCarta_230099
Vesiclepedia VP_230099
Entrez Gene 230099
UniProt Q8VHB5  
 Car9 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Car9
Molecular Function
    carbonate dehydratase activity GO:0004089 IBA
    carbonate dehydratase activity GO:0004089 ISO
    carbonate dehydratase activity GO:0004089 ISS
    zinc ion binding GO:0008270 ISO
    zinc ion binding GO:0008270 ISS
    molecular function activator activity GO:0140677 IEA
    molecular function activator activity GO:0140677 ISO
Biological Process
    response to hypoxia GO:0001666 IEA
    morphogenesis of an epithelium GO:0002009 IMP
    response to xenobiotic stimulus GO:0009410 IEA
    response to testosterone GO:0033574 IEA
    secretion GO:0046903 IMP
Subcellular Localization
    nucleolus GO:0005730 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    basolateral plasma membrane GO:0016323 IEA
    basolateral plasma membrane GO:0016323 ISO
    microvillus membrane GO:0031528 IEA
 Experiment description of studies that identified Car9 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Car9
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Car9 is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Reversible hydration of carbon dioxide IEA Reactome





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