Gene description for Tmem119
Gene name transmembrane protein 119
Gene symbol Tmem119
Other names/aliases AW208946
BC025600
obif
Species Mus musculus
 Database cross references - Tmem119
ExoCarta ExoCarta_231633
Vesiclepedia VP_231633
Entrez Gene 231633
UniProt Q8R138  
 Tmem119 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tmem119
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    osteoblast differentiation GO:0001649 IDA
    osteoblast differentiation GO:0001649 IMP
    positive regulation of protein phosphorylation GO:0001934 IDA
    endochondral ossification GO:0001958 IMP
    spermatogenesis GO:0007283 IMP
    positive regulation of gene expression GO:0010628 IDA
    positive regulation of gene expression GO:0010628 IMP
    negative regulation of myotube differentiation GO:0010832 IDA
    positive regulation of bone mineralization GO:0030501 IBA
    positive regulation of bone mineralization GO:0030501 IMP
    positive regulation of bone mineralization GO:0030501 ISO
    biomineral tissue development GO:0031214 IEA
    positive regulation of osteoblast proliferation GO:0033690 IBA
    positive regulation of osteoblast proliferation GO:0033690 IDA
    positive regulation of osteoblast proliferation GO:0033690 ISO
    positive regulation of osteoblast differentiation GO:0045669 IBA
    positive regulation of osteoblast differentiation GO:0045669 IDA
    positive regulation of osteoblast differentiation GO:0045669 IMP
    positive regulation of osteoblast differentiation GO:0045669 ISO
    negative regulation of bone resorption GO:0045779 IMP
    spermatid differentiation GO:0048515 IMP
    positive regulation of bone development GO:1903012 IMP
Subcellular Localization
    extracellular region GO:0005576 IEA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
 Experiment description of studies that identified Tmem119 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tmem119
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tmem119 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here