Gene description for Mat2a
Gene name methionine adenosyltransferase II, alpha
Gene symbol Mat2a
Other names/aliases D630045P18Rik
Species Mus musculus
 Database cross references - Mat2a
ExoCarta ExoCarta_232087
Vesiclepedia VP_232087
Entrez Gene 232087
UniProt Q3THS6  
 Mat2a identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mat2a
Molecular Function
    transferase activity GO:0016740 IEA
    amino acid binding GO:0016597 ISO
    nucleotide binding GO:0000166 IEA
    metal ion binding GO:0046872 IEA
    methionine adenosyltransferase activity GO:0004478 ISO
    ATP binding GO:0005524 ISO
Biological Process
    circadian rhythm GO:0007623 ISO
    one-carbon metabolic process GO:0006730 IEA
    response to hormone GO:0009725 ISO
    response to cAMP GO:0051591 ISO
    S-adenosylmethionine biosynthetic process GO:0006556 ISO
    response to drug GO:0042493 ISO
Subcellular Localization
    methionine adenosyltransferase complex GO:0048269 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Mat2a in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mat2a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mat2a is involved
PathwayEvidenceSource
Methylation IEA Reactome





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