Gene description for Klhl42
Gene name kelch-like 42
Gene symbol Klhl42
Other names/aliases A330079N23Rik
AI450355
C230080I20Rik
Ctb9
Klhdc5
mKIAA1340
Species Mus musculus
 Database cross references - Klhl42
ExoCarta ExoCarta_232539
Entrez Gene 232539
UniProt Q8BFQ9  
 Klhl42 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Klhl42
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 ISO
Biological Process
    cell cycle GO:0007049 IEA
    regulation of microtubule-based process GO:0032886 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    cell division GO:0051301 IEA
    protein polyubiquitination GO:0000209 ISO
    mitotic nuclear division GO:0007067 IEA
Subcellular Localization
    Cul3-RING ubiquitin ligase complex GO:0031463 ISO
    cytoplasm GO:0005737 IEA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified Klhl42 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Klhl42
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Klhl42 is involved
No pathways found





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