Gene description for Aars
Gene name alanyl-tRNA synthetase
Gene symbol Aars
Other names/aliases AI316495
Species Mus musculus
 Database cross references - Aars
ExoCarta ExoCarta_234734
Entrez Gene 234734
UniProt Q8BGQ7  
 Aars identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Aars
Molecular Function
    ligase activity GO:0016874 IEA
    ATP binding GO:0005524 ISO
    tRNA binding GO:0000049 ISO
    nucleotide binding GO:0000166 IEA
    nucleic acid binding GO:0003676 IEA
    ligase activity, forming aminoacyl-tRNA and related compounds GO:0016876 IEA
    aminoacyl-tRNA ligase activity GO:0004812 IEA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    RNA binding GO:0003723 IEA
    aminoacyl-tRNA editing activity GO:0002161 IDA
    alanine-tRNA ligase activity GO:0004813 ISO
    amino acid binding GO:0016597 ISO
Biological Process
    regulation of translational fidelity GO:0006450 IDA
    hair follicle development GO:0001942 IMP
    alanyl-tRNA aminoacylation GO:0006419 ISO
    endoplasmic reticulum unfolded protein response GO:0030968 IMP
    response to amino acid GO:0043200 IMP
    cellular response to unfolded protein GO:0034620 IMP
    neuromuscular process GO:0050905 IMP
    translation GO:0006412 IEA
    tRNA modification GO:0006400 IMP
    protein folding GO:0006457 IMP
    skin development GO:0043588 IMP
    cerebellar Purkinje cell layer development GO:0021680 IMP
    negative regulation of neuron apoptotic process GO:0043524 IMP
    neuromuscular process controlling balance GO:0050885 IMP
    tRNA aminoacylation GO:0043039 IEA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Aars in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Aars
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aars is involved
No pathways found

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