Gene description for Cd109
Gene name CD109 antigen
Gene symbol Cd109
Other names/aliases 9930012E15Rik
AI480638
GARP
Species Mus musculus
 Database cross references - Cd109
ExoCarta ExoCarta_235505
Vesiclepedia VP_235505
Entrez Gene 235505
UniProt Q8R422  
 Cd109 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
Fibroblasts 23260141    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Cd109
Molecular Function
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
    transforming growth factor beta binding GO:0050431 ISO
Biological Process
    negative regulation of protein phosphorylation GO:0001933 IMP
    hair follicle development GO:0001942 IMP
    protein phosphorylation GO:0006468 IMP
    negative regulation of keratinocyte proliferation GO:0010839 IMP
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IEA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 ISO
    keratinocyte proliferation GO:0043616 IMP
    regulation of keratinocyte differentiation GO:0045616 IMP
    negative regulation of wound healing GO:0061045 IEA
    negative regulation of wound healing GO:0061045 ISO
    stem cell proliferation GO:0072089 IMP
    osteoclast fusion GO:0072675 IMP
    negative regulation of stem cell proliferation GO:2000647 IMP
Subcellular Localization
    extracellular space GO:0005615 HDA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified Cd109 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 210
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Cd109
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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