Gene description for FPR3
Gene name formyl peptide receptor 3
Gene symbol FPR3
Other names/aliases FML2_HUMAN
FMLPY
FPRH1
FPRH2
FPRL2
RMLP-R-I
Species Homo sapiens
 Database cross references - FPR3
ExoCarta ExoCarta_2359
Vesiclepedia VP_2359
Entrez Gene 2359
HGNC 3828
MIM 136539
UniProt P25089  
 FPR3 identified in sEVs derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for FPR3
Molecular Function
    complement receptor activity GO:0004875 IBA
    N-formyl peptide receptor activity GO:0004982 IBA
    protein binding GO:0005515 IPI
Biological Process
    complement receptor mediated signaling pathway GO:0002430 IBA
    chemotaxis GO:0006935 IEA
    inflammatory response GO:0006954 IBA
    signal transduction GO:0007165 TAS
    phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IBA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IBA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 TAS
 Experiment description of studies that identified FPR3 in sEVs
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for FPR3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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