Gene description for LSM5
Gene name LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Gene symbol LSM5
Other names/aliases YER146W
Species Homo sapiens
 Database cross references - LSM5
ExoCarta ExoCarta_23658
Entrez Gene 23658
HGNC 17162
MIM 607285
UniProt Q9Y4Y9  
 LSM5 identified in exosomes derived from the following tissue/cell type
Plasma 23663360    
 Gene ontology annotations for LSM5
Molecular Function
    RNA binding GO:0003723 IEA
    protein binding GO:0005515 IPI
Biological Process
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
    RNA splicing GO:0008380 IEA
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0043928 TAS
    gene expression GO:0010467 TAS
    mRNA processing GO:0006397 IEA
Subcellular Localization
    nucleus GO:0005634 TAS
    spliceosomal complex GO:0005681 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified LSM5 in exosomes
1
Experiment ID 222
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule snRNA
Identification method RT-PCR
PubMed ID 23663360    
Organism Homo sapiens
Experiment description Characterization of human plasma-derived exosomal RNAs by deep sequencing
Authors Huang X, Yuan T, Tschannen M, Sun Z, Jacob H, Du M, Liang M, Dittmar RL, Liu Y, Liang M, Kohli M, Thibodeau SN, Boardman L, Wang L
Journal name BMC Genomics
Publication year 2013
Sample Plasma
Sample name Plasma - Normal
Isolation/purification methods Exoquick
Flotation density -
Molecules identified in the study miRNA
tRNA
snRNA
snoRNA
rRNA
piRNA
lncRNA
Methods used in the study RT-PCR
 Protein-protein interactions for LSM5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LSM1  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 LSM8  
Invitro Homo sapiens
3 HNRNPD 3184
Two-hybrid Homo sapiens
4 LSM2  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
5 LSM7  
Invitro Homo sapiens
6 LSM4  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
7 SMN1 6606
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
8 SNRPE 6635
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
9 LSM3 27258
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
10 LSM6 11157
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
11 SNRPF 6636
Two-hybrid Homo sapiens
12 EXOSC5 56915
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which LSM5 is involved
PathwayEvidenceSource
mRNA decay by 5' to 3' exoribonuclease TAS Reactome





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