Gene description for Adamts5
Gene name a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
Gene symbol Adamts5
Other names/aliases 9530092O11Rik
ADAM-TS5
ADAMTS1
ADAMTS11
AI481094
ASMP-2
Species Mus musculus
 Database cross references - Adamts5
ExoCarta ExoCarta_23794
Entrez Gene 23794
UniProt Q9R001  
 Adamts5 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Adamts5
Molecular Function
    metal ion binding GO:0046872 IEA
    metalloendopeptidase activity GO:0004222 IEA
    metallopeptidase activity GO:0008237 ISO
    hydrolase activity GO:0016787 IEA
    zinc ion binding GO:0008270 IEA
    peptidase activity GO:0008233 IEA
Biological Process
    defense response to bacterium GO:0042742 IGI
    proteolysis GO:0006508 ISO
Subcellular Localization
    extracellular matrix GO:0031012 IEA
    extracellular region GO:0005576 IEA
    proteinaceous extracellular matrix GO:0005578 IEA
 Experiment description of studies that identified Adamts5 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Adamts5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adamts5 is involved
PathwayEvidenceSource
Degradation of the extracellular matrix IEA Reactome
O-glycosylation of TSR domain-containing proteins IEA Reactome





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