Gene description for Adamts5
Gene name	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
Gene symbol	Adamts5
Other names/aliases	9530092O11Rik ADAM-TS5 ADAMTS1 ADAMTS11 AI481094 ASMP-2
Species	Mus musculus
Database cross references - Adamts5
ExoCarta	ExoCarta_23794
Vesiclepedia	VP_23794
Entrez Gene	23794
UniProt	Q9R001
Adamts5 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Adamts5

Molecular Function     endopeptidase activity GO:0004175 IMP     metalloendopeptidase activity GO:0004222 IBA     metalloendopeptidase activity GO:0004222 ISO     metalloendopeptidase activity GO:0004222 ISS     metalloendopeptidase activity GO:0004222 TAS     heparin binding GO:0008201 IDA     peptidase activity GO:0008233 ISO     peptidase activity GO:0008233 ISS     metallopeptidase activity GO:0008237 IDA     metallopeptidase activity GO:0008237 ISO     zinc ion binding GO:0008270 IEA     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO     extracellular matrix binding GO:0050840 IDA Biological Process     aortic valve morphogenesis GO:0003180 IMP     pulmonary valve morphogenesis GO:0003184 IMP     endocardial cushion morphogenesis GO:0003203 IGI     proteolysis GO:0006508 IBA     proteolysis GO:0006508 IEA     myoblast fusion GO:0007520 IMP     extracellular matrix disassembly GO:0022617 IMP     extracellular matrix organization GO:0030198 IBA     extracellular matrix organization GO:0030198 TAS     defense response to bacterium GO:0042742 IGI     negative regulation of cold-induced thermogenesis GO:0120163 IMP Subcellular Localization     extracellular space GO:0005615 HDA     extracellular space GO:0005615 IDA     extracellular matrix GO:0031012 IBA     collagen-containing extracellular matrix GO:0062023 IEA