Gene description for Dock4
Gene name dedicator of cytokinesis 4
Gene symbol Dock4
Other names/aliases 5330406C03
6330411N01Rik
AF263288
C030023J22
mKIAA0716
Species Mus musculus
 Database cross references - Dock4
ExoCarta ExoCarta_238130
Entrez Gene 238130
UniProt P59764  
 Dock4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Dock4
Molecular Function
    SH3 domain binding GO:0017124 IEA
    guanyl-nucleotide exchange factor activity GO:0005085 IEA
    GTPase activator activity GO:0005096 ISO
    Rac GTPase binding GO:0048365 ISO
    receptor tyrosine kinase binding GO:0030971 ISO
    PDZ domain binding GO:0030165 ISO
Biological Process
    positive regulation of GTPase activity GO:0043547 ISO
    cell chemotaxis GO:0060326 ISO
    small GTPase mediated signal transduction GO:0007264 IEA
Subcellular Localization
    stereocilium bundle GO:0032421 IDA
    cytosol GO:0005829 ISO
    membrane GO:0016020 ISO
    stereocilium GO:0032420 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified Dock4 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Dock4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Dock4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here