Gene description for Gdf15
Gene name growth differentiation factor 15
Gene symbol Gdf15
Other names/aliases MIC-1
Species Mus musculus
 Database cross references - Gdf15
ExoCarta ExoCarta_23886
Entrez Gene 23886
UniProt Q9Z0J7  
 Gdf15 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Gdf15
Molecular Function
    cytokine activity GO:0005125 IBA
    growth factor activity GO:0008083 IEA
    transforming growth factor beta receptor binding GO:0005160 IBA
Biological Process
    positive regulation of myoblast fusion GO:1901741 IMP
    regulation of MAPK cascade GO:0043408 IBA
    positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 IBA
    cell development GO:0048468 IBA
    regulation of apoptotic process GO:0042981 IBA
    SMAD protein signal transduction GO:0060395 IBA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular region GO:0005576 IEA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Gdf15 in exosomes
Experiment ID 210
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Gdf15
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gdf15 is involved
No pathways found

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