Gene description for Gdf15
Gene name growth differentiation factor 15
Gene symbol Gdf15
Other names/aliases MIC-1
NAG-1
SBF
Species Mus musculus
 Database cross references - Gdf15
ExoCarta ExoCarta_23886
Vesiclepedia VP_23886
Entrez Gene 23886
UniProt Q9Z0J7  
 Gdf15 identified in sEVs derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Gdf15
Molecular Function
    cytokine activity GO:0005125 IBA
    cytokine activity GO:0005125 IDA
    cytokine activity GO:0005125 IMP
    cytokine activity GO:0005125 ISO
    hormone activity GO:0005179 IDA
    hormone activity GO:0005179 IMP
    hormone activity GO:0005179 ISO
    growth factor activity GO:0008083 IEA
    protein homodimerization activity GO:0042803 IDA
    protein homodimerization activity GO:0042803 ISO
Biological Process
    reduction of food intake in response to dietary excess GO:0002023 IDA
    reduction of food intake in response to dietary excess GO:0002023 IMP
    reduction of food intake in response to dietary excess GO:0002023 ISO
    reduction of food intake in response to dietary excess GO:0002023 ISS
    negative regulation of leukocyte migration GO:0002686 IMP
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IEA
    negative regulation of appetite GO:0032099 IDA
    negative regulation of appetite GO:0032099 IMP
    negative regulation of appetite GO:0032099 ISO
    negative regulation of multicellular organism growth GO:0040015 IDA
    positive regulation of MAPK cascade GO:0043410 IMP
    positive regulation of MAPK cascade GO:0043410 ISO
    positive regulation of MAPK cascade GO:0043410 ISS
    positive regulation of fatty acid oxidation GO:0046321 IDA
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO
    positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISS
    negative regulation of SMAD protein signal transduction GO:0060392 ISO
    negative regulation of SMAD protein signal transduction GO:0060392 ISS
    negative regulation of growth hormone receptor signaling pathway GO:0060400 IDA
    cellular response to chemical stress GO:0062197 IDA
    cellular response to chemical stress GO:0062197 IMP
    energy homeostasis GO:0097009 IDA
    GDF15-GFRAL signaling pathway GO:0160144 IDA
    GDF15-GFRAL signaling pathway GO:0160144 IMP
    GDF15-GFRAL signaling pathway GO:0160144 ISO
    response to metformin GO:1901558 IDA
    response to metformin GO:1901558 ISO
    positive regulation of myoblast fusion GO:1901741 IMP
Subcellular Localization
    extracellular region GO:0005576 IDA
    extracellular region GO:0005576 ISO
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISO
    extracellular space GO:0005615 ISS
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISO
    cytoplasm GO:0005737 ISS
    Golgi apparatus GO:0005794 IEA
    Golgi apparatus GO:0005794 ISO
 Experiment description of studies that identified Gdf15 in sEVs
1
Experiment ID 210
MISEV standards
EM
Biophysical techniques
CD81|FLOT1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors "Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL."
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Gdf15
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gdf15 is involved
No pathways found





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