Gene description for Kctd12
Gene name potassium channel tetramerisation domain containing 12
Gene symbol Kctd12
Other names/aliases AU046135
AW538430
Pfet1
Pfetin
Species Mus musculus
 Database cross references - Kctd12
ExoCarta ExoCarta_239217
Vesiclepedia VP_239217
Entrez Gene 239217
UniProt Q6WVG3  
 Kctd12 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Kctd12
Molecular Function
    poly(A) RNA binding GO:0044822 ISO
    protein binding GO:0005515 IPI
Biological Process
    regulation of G-protein coupled receptor protein signaling pathway GO:0008277 IGI
    protein homooligomerization GO:0051260 IEA
Subcellular Localization
    postsynaptic membrane GO:0045211 IDA
    membrane GO:0016020 IEA
    presynaptic membrane GO:0042734 IDA
    cell junction GO:0030054 IEA
    receptor complex GO:0043235 IDA
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 ISO
    synapse GO:0045202 IEA
 Experiment description of studies that identified Kctd12 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Kctd12
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Kctd12 is involved
No pathways found





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