Gene description for Esyt1
Gene name extended synaptotagmin-like protein 1
Gene symbol Esyt1
Other names/aliases Fam62a
Mbc2
vp115
Species Mus musculus
 Database cross references - Esyt1
ExoCarta ExoCarta_23943
Vesiclepedia VP_23943
Entrez Gene 23943
UniProt Q3U7R1  
 Esyt1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Esyt1
Molecular Function
    metal ion binding GO:0046872 IEA
    phospholipid binding GO:0005543 IBA
    lipid binding GO:0008289 IEA
Biological Process
    transport GO:0006810 IEA
    lipid transport GO:0006869 IEA
Subcellular Localization
    integral component of endoplasmic reticulum membrane GO:0030176 ISO
    membrane GO:0016020 ISO
    integral component of membrane GO:0016021 IEA
    organelle membrane contact site GO:0044232 IBA
    plasma membrane GO:0005886 IEA
    endoplasmic reticulum GO:0005783 IBA
    intrinsic component of endoplasmic reticulum membrane GO:0031227 IBA
 Experiment description of studies that identified Esyt1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Esyt1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Esyt1 is involved
No pathways found





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