Gene description for Tenm4
Gene name teneurin transmembrane protein 4
Gene symbol Tenm4
Other names/aliases Doc4
ELM2
Odz4
R75022
Ten-m4
l(7)-3Rn
l7Rn3
mKIAA1302
Species Mus musculus
 Database cross references - Tenm4
ExoCarta ExoCarta_23966
Entrez Gene 23966
UniProt Q3UHK6  
 Tenm4 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tenm4
Molecular Function
    protein homodimerization activity GO:0042803 IDA
Biological Process
    positive regulation of gastrulation GO:2000543 IMP
    signal transduction GO:0007165 IEA
    central nervous system myelin formation GO:0032289 IMP
    cell differentiation GO:0030154 IEA
    neuron development GO:0048666 IEA
    positive regulation of oligodendrocyte differentiation GO:0048714 IMP
    self proteolysis GO:0097264 IEA
    multicellular organismal development GO:0007275 IEA
    cardiac cell fate specification GO:0060912 IMP
    positive regulation of myelination GO:0031643 IMP
    cardiac muscle cell proliferation GO:0060038 IMP
    gastrulation with mouth forming second GO:0001702 IMP
Subcellular Localization
    neuron projection GO:0043005 IDA
    nucleus GO:0005634 IDA
    integral component of membrane GO:0016021 IEA
    integral component of plasma membrane GO:0005887 IEA
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 IEA
    cell projection GO:0042995 IEA
 Experiment description of studies that identified Tenm4 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tenm4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tenm4 is involved
No pathways found





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