Gene description for Tenm4
Gene name teneurin transmembrane protein 4
Gene symbol Tenm4
Other names/aliases Doc4
ELM2
Odz4
R75022
Ten-m4
l(7)-3Rn
l7Rn3
mKIAA1302
Species Mus musculus
 Database cross references - Tenm4
ExoCarta ExoCarta_23966
Vesiclepedia VP_23966
Entrez Gene 23966
UniProt Q3UHK6  
 Tenm4 identified in sEVs derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Tenm4
Molecular Function
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IBA
    protein homodimerization activity GO:0042803 IDA
    protein heterodimerization activity GO:0046982 IBA
    cell adhesion molecule binding GO:0050839 IBA
Biological Process
    gastrulation with mouth forming second GO:0001702 IMP
    signal transduction GO:0007165 IEA
    regulation of myelination GO:0031641 ISO
    regulation of myelination GO:0031641 ISS
    positive regulation of myelination GO:0031643 IMP
    central nervous system myelin formation GO:0032289 IMP
    central nervous system myelin formation GO:0032289 ISO
    central nervous system myelin formation GO:0032289 ISS
    neuron development GO:0048666 IBA
    neuron development GO:0048666 ISO
    neuron development GO:0048666 ISS
    positive regulation of oligodendrocyte differentiation GO:0048714 IMP
    cardiac muscle cell proliferation GO:0060038 IMP
    cardiac cell fate specification GO:0060912 IMP
    synaptic membrane adhesion GO:0099560 IDA
    synaptic membrane adhesion GO:0099560 NAS
    positive regulation of gastrulation GO:2000543 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISO
    plasma membrane GO:0005886 ISS
    neuron projection GO:0043005 IBA
    neuron projection GO:0043005 IDA
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 NAS
 Experiment description of studies that identified Tenm4 in sEVs
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Tenm4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Tenm1  
Co-fractionation Mus musculus
2 Slc25a10  
Co-fractionation Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 Olfm1  
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
5 Usp7  
Affinity Capture-MS Mus musculus
6 Sstr3  
Proximity Label-MS Mus musculus
View the network image/svg+xml
 Pathways in which Tenm4 is involved
No pathways found





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