Gene description for Pebp1
Gene name phosphatidylethanolamine binding protein 1
Gene symbol Pebp1
Other names/aliases HCNP
Pbp
Pbp1
Pbpr
Rkip
Species Mus musculus
 Database cross references - Pebp1
ExoCarta ExoCarta_23980
Entrez Gene 23980
UniProt P70296  
 Pebp1 identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
Oligodendrocytes 21136642    
Pancreatic cells 19351151    
 Gene ontology annotations for Pebp1
Molecular Function
    protein kinase binding GO:0019901 ISO
    receptor binding GO:0005102 ISO
    nucleotide binding GO:0000166 IEA
    kinase binding GO:0019900 ISO
    serine-type endopeptidase inhibitor activity GO:0004867 IEA
    poly(A) RNA binding GO:0044822 ISO
    peptidase inhibitor activity GO:0030414 IEA
    mitogen-activated protein kinase binding GO:0051019 ISO
    enzyme binding GO:0019899 ISO
    lipid binding GO:0008289 IEA
    ATP binding GO:0005524 ISO
Biological Process
    positive regulation of acetylcholine metabolic process GO:0060409 ISO
    sperm capacitation GO:0048240 IDA
    negative regulation of protein phosphorylation GO:0001933 ISO
    positive regulation of mitotic nuclear division GO:0045840 ISO
    regulation of neurotransmitter levels GO:0001505 ISO
    negative regulation of peptidase activity GO:0010466 IEA
    MAPK cascade GO:0000165 ISO
    positive regulation of cAMP-mediated signaling GO:0043950 ISO
    negative regulation of MAPK cascade GO:0043409 ISO
    regulation of the force of heart contraction GO:0002026 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    extracellular space GO:0005615 ISO
    cell surface GO:0009986 ISO
    rough endoplasmic reticulum GO:0005791 ISO
    cytoplasm GO:0005737 ISO
    neuron projection GO:0043005 ISO
    myelin sheath GO:0043209 IDA
    mitochondrion GO:0005739 ISO
    axon terminus GO:0043679 ISO
    Golgi apparatus GO:0005794 ISO
    apical part of cell GO:0045177 ISO
    neuronal cell body GO:0043025 ISO
    nucleus GO:0005634 ISO
    synaptic vesicle GO:0008021 ISO
    mitochondrial outer membrane GO:0005741 ISO
 Experiment description of studies that identified Pebp1 in exosomes
1
Experiment ID 39
ISEV standards
IEM
EV Biophysical techniques
TSG101|HSC70
EV Cytosolic markers
FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
3
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pebp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pebp1 is involved
No pathways found





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