Gene description for Ada
Gene name	adenosine deaminase
Gene symbol	Ada
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Ada
ExoCarta	ExoCarta_24165
Vesiclepedia	VP_24165
Entrez Gene	24165
UniProt	Q920P6
Ada identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Ada

Molecular Function     purine nucleoside binding GO:0001883 IDA     adenosine deaminase activity GO:0004000 IBA     adenosine deaminase activity GO:0004000 IDA     adenosine deaminase activity GO:0004000 IEA     adenosine deaminase activity GO:0004000 ISO     adenosine deaminase activity GO:0004000 ISS     zinc ion binding GO:0008270 IEA     zinc ion binding GO:0008270 ISO     zinc ion binding GO:0008270 ISS     deaminase activity GO:0019239 ISO     2'-deoxyadenosine deaminase activity GO:0046936 IEA     2'-deoxyadenosine deaminase activity GO:0046936 ISO Biological Process     allantoin metabolic process GO:0000255 IEA     allantoin metabolic process GO:0000255 ISO     response to hypoxia GO:0001666 IEA     response to hypoxia GO:0001666 IMP     response to hypoxia GO:0001666 ISO     in utero embryonic development GO:0001701 ISO     histamine secretion GO:0001821 IMP     trophectodermal cell differentiation GO:0001829 IEA     trophectodermal cell differentiation GO:0001829 ISO     liver development GO:0001889 IEA     liver development GO:0001889 ISO     placenta development GO:0001890 IEA     placenta development GO:0001890 ISO     germinal center B cell differentiation GO:0002314 IEA     germinal center B cell differentiation GO:0002314 ISO     germinal center formation GO:0002467 IEA     germinal center formation GO:0002467 ISO     positive regulation of germinal center formation GO:0002636 IEA     positive regulation of germinal center formation GO:0002636 ISO     negative regulation of leukocyte migration GO:0002686 IEA     negative regulation of leukocyte migration GO:0002686 ISO     mature B cell apoptotic process GO:0002901 IEA     mature B cell apoptotic process GO:0002901 ISO     negative regulation of mature B cell apoptotic process GO:0002906 IEA     negative regulation of mature B cell apoptotic process GO:0002906 ISO     adenosine catabolic process GO:0006154 IBA     adenosine catabolic process GO:0006154 IEA     adenosine catabolic process GO:0006154 IMP     adenosine catabolic process GO:0006154 ISO     adenosine catabolic process GO:0006154 ISO     adenosine catabolic process GO:0006154 ISS     deoxyadenosine catabolic process GO:0006157 IEA     deoxyadenosine catabolic process GO:0006157 ISO     deoxyadenosine catabolic process GO:0006157 ISO     AMP catabolic process GO:0006196 IEA     AMP catabolic process GO:0006196 ISO     apoptotic process GO:0006915 ISO     smooth muscle contraction GO:0006939 IEA     smooth muscle contraction GO:0006939 ISO     cell adhesion GO:0007155 IEA     purine ribonucleoside monophosphate biosynthetic process GO:0009168 IEA     response to xenobiotic stimulus GO:0009410 IEP     positive regulation of heart rate GO:0010460 IEA     positive regulation of heart rate GO:0010460 ISO     response to purine-containing compound GO:0014074 IEA     response to purine-containing compound GO:0014074 ISO     calcium-mediated signaling GO:0019722 IEA     calcium-mediated signaling GO:0019722 ISO     T cell differentiation GO:0030217 ISO     lung development GO:0030324 ISO     positive regulation of B cell proliferation GO:0030890 IEA     positive regulation of B cell proliferation GO:0030890 ISO     purine nucleotide salvage GO:0032261 ISO     GMP salvage GO:0032263 IEA     GMP salvage GO:0032263 ISO     T cell differentiation in thymus GO:0033077 IEA     T cell differentiation in thymus GO:0033077 ISO     regulation of T cell differentiation in thymus GO:0033081 IMP     positive regulation of T cell differentiation in thymus GO:0033089 IEA     positive regulation of T cell differentiation in thymus GO:0033089 ISO     response to vitamin E GO:0033197 IDA     regulation of cell-cell adhesion mediated by integrin GO:0033632 IEA     regulation of cell-cell adhesion mediated by integrin GO:0033632 ISO     B cell proliferation GO:0042100 IEA     B cell proliferation GO:0042100 ISO     T cell activation GO:0042110 IBA     T cell activation GO:0042110 ISO     T cell activation GO:0042110 ISO     negative regulation of circadian sleep/wake cycle, non-REM sleep GO:0042323 IMP     response to hydrogen peroxide GO:0042542 IEP     negative regulation of apoptotic process GO:0043066 ISO     penile erection GO:0043084 IEA     penile erection GO:0043084 ISO     hypoxanthine salvage GO:0043103 IBA     amide catabolic process GO:0043605 IEA     amide catabolic process GO:0043605 ISO     AMP salvage GO:0044209 IEA     AMP salvage GO:0044209 ISO     regulation of circadian sleep/wake cycle, sleep GO:0045187 IEP     regulation of T cell differentiation GO:0045580 ISO     positive regulation of T cell differentiation GO:0045582 ISO     positive regulation of smooth muscle contraction GO:0045987 IEA     positive regulation of smooth muscle contraction GO:0045987 ISO     dAMP catabolic process GO:0046059 IEA     dAMP catabolic process GO:0046059 ISO     dATP catabolic process GO:0046061 IEA     dATP catabolic process GO:0046061 ISO     adenosine metabolic process GO:0046085 IDA     adenosine metabolic process GO:0046085 ISO     adenosine metabolic process GO:0046085 TAS     hypoxanthine biosynthetic process GO:0046101 IEA     hypoxanthine biosynthetic process GO:0046101 ISO     inosine biosynthetic process GO:0046103 IBA     inosine biosynthetic process GO:0046103 IEA     inosine biosynthetic process GO:0046103 ISO     inosine biosynthetic process GO:0046103 ISO     inosine biosynthetic process GO:0046103 ISS     xanthine biosynthetic process GO:0046111 IEA     xanthine biosynthetic process GO:0046111 ISO     alpha-beta T cell differentiation GO:0046632 IEA     alpha-beta T cell differentiation GO:0046632 ISO     positive regulation of alpha-beta T cell differentiation GO:0046638 IEA     positive regulation of alpha-beta T cell differentiation GO:0046638 ISO     response to cadmium ion GO:0046686 IEP     lung alveolus development GO:0048286 IEA     lung alveolus development GO:0048286 ISO     Peyer's patch development GO:0048541 IEA     Peyer's patch development GO:0048541 ISO     embryonic digestive tract development GO:0048566 IEA     embryonic digestive tract development GO:0048566 ISO     negative regulation of inflammatory response GO:0050728 IEA     negative regulation of inflammatory response GO:0050728 ISO     positive regulation of calcium-mediated signaling GO:0050850 IEA     positive regulation of calcium-mediated signaling GO:0050850 ISO     T cell receptor signaling pathway GO:0050852 IEA     T cell receptor signaling pathway GO:0050852 ISO     positive regulation of T cell receptor signaling pathway GO:0050862 IEA     positive regulation of T cell receptor signaling pathway GO:0050862 ISO     positive regulation of T cell activation GO:0050870 ISO     leukocyte migration GO:0050900 IEA     leukocyte migration GO:0050900 ISO     negative regulation of adenosine receptor signaling pathway GO:0060169 IBA     negative regulation of adenosine receptor signaling pathway GO:0060169 IEA     negative regulation of adenosine receptor signaling pathway GO:0060169 ISO     negative regulation of penile erection GO:0060407 IEA     negative regulation of penile erection GO:0060407 ISO     thymocyte apoptotic process GO:0070242 IEA     thymocyte apoptotic process GO:0070242 ISO     negative regulation of thymocyte apoptotic process GO:0070244 IEA     negative regulation of thymocyte apoptotic process GO:0070244 ISO     mucus secretion GO:0070254 IEA     mucus secretion GO:0070254 ISO     negative regulation of mucus secretion GO:0070256 IEA     negative regulation of mucus secretion GO:0070256 ISO     response to L-arginine GO:1903576 IEP Subcellular Localization     extracellular space GO:0005615 IDA     cytoplasm GO:0005737 ISO     lysosome GO:0005764 IEA     lysosome GO:0005764 ISO     cytosol GO:0005829 IBA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISO     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     external side of plasma membrane GO:0009897 IBA     external side of plasma membrane GO:0009897 IEA     external side of plasma membrane GO:0009897 ISO     cell surface GO:0009986 ISO     membrane GO:0016020 ISO     dendrite cytoplasm GO:0032839 IDA     neuronal cell body GO:0043025 IDA     cytoplasmic vesicle lumen GO:0060205 IEA     anchoring junction GO:0070161 IEA