Gene description for Adcyap1
Gene name adenylate cyclase activating polypeptide 1
Gene symbol Adcyap1
Other names/aliases Pacap
Species Rattus norvegicus
 Database cross references - Adcyap1
ExoCarta ExoCarta_24166
Entrez Gene 24166
UniProt P13589  
 Adcyap1 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Adcyap1
Molecular Function
    peptide hormone receptor binding GO:0051428 ISS
    pituitary adenylate cyclase activating polypeptide activity GO:0016521 ISO
    receptor signaling protein activity GO:0005057 ISO
    pituitary adenylate cyclase-activating polypeptide receptor binding GO:0031858 IDA
    neuropeptide hormone activity GO:0005184 ISO
    receptor binding GO:0005102 ISO
Biological Process
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    behavioral fear response GO:0001662 IDA
    negative regulation of GTPase activity GO:0034260 IDA
    neuron projection development GO:0031175 ISO
    positive regulation of neuron projection development GO:0010976 IDA
    positive regulation of somatostatin secretion GO:0090274 IDA
    neuropeptide signaling pathway GO:0007218 NAS
    positive regulation of growth hormone secretion GO:0060124 IDA
    response to starvation GO:0042594 IEP
    negative regulation of muscle cell apoptotic process GO:0010656 IDA
    ovarian follicle development GO:0001541 IDA
    intracellular signal transduction GO:0035556 ISO
    positive regulation of cell proliferation GO:0008284 IDA
    pituitary gland development GO:0021983 IEP
    sensory perception of pain GO:0019233 IDA
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IDA
    negative regulation of glial cell proliferation GO:0060253 IDA
    regulation of G-protein coupled receptor protein signaling pathway GO:0008277 ISS
    ATP metabolic process GO:0046034 IDA
    negative regulation of cell cycle GO:0045786 ISO
    positive regulation of protein kinase activity GO:0045860 ISO
    positive regulation of gene expression GO:0010628 ISO
    positive regulation of interleukin-6 production GO:0032755 IDA
    positive regulation of cAMP biosynthetic process GO:0030819 IDA
    response to ethanol GO:0045471 IEP
    positive regulation of cytosolic calcium ion concentration GO:0007204 IDA
    regulation of oligodendrocyte progenitor proliferation GO:0070445 IDA
    positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway GO:0010579 ISO
    positive regulation of GTPase activity GO:0043547 ISO
    regulation of postsynaptic membrane potential GO:0060078 IDA
    cAMP-mediated signaling GO:0019933 ISO
    negative regulation of potassium ion transport GO:0043267 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    negative regulation of acute inflammatory response to antigenic stimulus GO:0002865 IDA
    positive regulation of chemokine (C-C motif) ligand 5 production GO:0071651 ISO
    positive regulation of vasodilation GO:0045909 IDA
    negative regulation of acute inflammatory response to non-antigenic stimulus GO:0002878 IDA
    regulation of protein localization GO:0032880 ISO
    histamine secretion GO:0001821 IDA
    cellular response to glucocorticoid stimulus GO:0071385 IEP
Subcellular Localization
    intracellular GO:0005622 ISO
    terminal bouton GO:0043195 IDA
    extracellular space GO:0005615 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified Adcyap1 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Adcyap1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adcyap1 is involved
PathwayEvidenceSource
G alpha (s) signalling events IEA Reactome
Glucagon-type ligand receptors IEA Reactome
NGF-independant TRKA activation IEA Reactome





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