Gene description for Adcyap1
Gene name	adenylate cyclase activating polypeptide 1
Gene symbol	Adcyap1
Other names/aliases	Pacap
Species	Rattus norvegicus
Database cross references - Adcyap1
ExoCarta	ExoCarta_24166
Vesiclepedia	VP_24166
Entrez Gene	24166
UniProt	P13589
Adcyap1 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Adcyap1

Molecular Function     signaling receptor binding GO:0005102 ISO     neuropeptide hormone activity GO:0005184 IBA     neuropeptide hormone activity GO:0005184 IDA     neuropeptide hormone activity GO:0005184 IEA     neuropeptide hormone activity GO:0005184 ISO     pituitary adenylate cyclase activating polypeptide activity GO:0016521 IBA     pituitary adenylate cyclase activating polypeptide activity GO:0016521 IDA     pituitary adenylate cyclase activating polypeptide activity GO:0016521 IEA     pituitary adenylate cyclase activating polypeptide activity GO:0016521 ISO     pituitary adenylate cyclase-activating polypeptide receptor binding GO:0031858 IDA     type 1 vasoactive intestinal polypeptide receptor binding GO:0031891 ISO     type 1 vasoactive intestinal polypeptide receptor binding GO:0031891 ISS     type 2 vasoactive intestinal polypeptide receptor binding GO:0031892 ISO     type 2 vasoactive intestinal polypeptide receptor binding GO:0031892 ISS     peptide hormone receptor binding GO:0051428 IBA     peptide hormone receptor binding GO:0051428 ISO     peptide hormone receptor binding GO:0051428 ISS Biological Process     ovarian follicle development GO:0001541 IDA     behavioral fear response GO:0001662 IDA     histamine secretion GO:0001821 IDA     regulation of protein phosphorylation GO:0001932 IGI     negative regulation of acute inflammatory response to antigenic stimulus GO:0002865 IDA     negative regulation of acute inflammatory response to non-antigenic stimulus GO:0002878 IDA     adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 IMP     adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 ISO     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IBA     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IDA     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 IEA     adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 ISO     positive regulation of cytosolic calcium ion concentration GO:0007204 IDA     neuropeptide signaling pathway GO:0007218 IBA     neuropeptide signaling pathway GO:0007218 IDA     neuropeptide signaling pathway GO:0007218 ISO     neuropeptide signaling pathway GO:0007218 NAS     regulation of G protein-coupled receptor signaling pathway GO:0008277 ISO     regulation of G protein-coupled receptor signaling pathway GO:0008277 ISS     positive regulation of cell population proliferation GO:0008284 IDA     positive regulation of gene expression GO:0010628 IEA     positive regulation of gene expression GO:0010628 ISO     negative regulation of muscle cell apoptotic process GO:0010656 IDA     positive regulation of neuron projection development GO:0010976 IDA     positive regulation of neuron projection development GO:0010976 IGI     pituitary gland development GO:0021983 IEP     insulin secretion GO:0030073 IEA     insulin secretion GO:0030073 ISO     insulin secretion GO:0030073 ISS     neuron projection development GO:0031175 IBA     neuron projection development GO:0031175 IDA     neuron projection development GO:0031175 ISO     positive regulation of interleukin-6 production GO:0032755 IDA     regulation of protein localization GO:0032880 IBA     regulation of protein localization GO:0032880 IDA     regulation of protein localization GO:0032880 IEA     regulation of protein localization GO:0032880 ISO     negative regulation of GTPase activity GO:0034260 IDA     vasodilation GO:0042311 IDA     response to starvation GO:0042594 IEP     negative regulation of potassium ion transport GO:0043267 IDA     positive regulation of GTPase activity GO:0043547 IDA     positive regulation of GTPase activity GO:0043547 ISO     response to ethanol GO:0045471 IEP     negative regulation of cell cycle GO:0045786 IEA     negative regulation of cell cycle GO:0045786 ISO     positive regulation of protein kinase activity GO:0045860 IDA     positive regulation of protein kinase activity GO:0045860 ISO     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 ISO     positive regulation of synaptic transmission, glutamatergic GO:0051968 IDA     regulation of postsynaptic membrane potential GO:0060078 IDA     positive regulation of growth hormone secretion GO:0060124 IDA     negative regulation of glial cell proliferation GO:0060253 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IBA     positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     regulation of oligodendrocyte progenitor proliferation GO:0070445 IDA     cellular response to glucocorticoid stimulus GO:0071385 IEP     positive regulation of chemokine (C-C motif) ligand 5 production GO:0071651 ISO     positive regulation of somatostatin secretion GO:0090274 IDA     positive regulation of cold-induced thermogenesis GO:0120162 ISO     positive regulation of cold-induced thermogenesis GO:0120162 ISS     positive regulation of cAMP/PKA signal transduction GO:0141163 IDA Subcellular Localization     extracellular region GO:0005576 IEA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     cytosol GO:0005829 TAS     neuron projection GO:0043005 IBA     terminal bouton GO:0043195 IDA     perikaryon GO:0043204 IBA     neuronal dense core vesicle lumen GO:0099013 IDA