Gene description for Aldh1a1
Gene name aldehyde dehydrogenase 1 family, member A1
Gene symbol Aldh1a1
Other names/aliases Ahd2
Aldh1
Aldh2
Species Rattus norvegicus
 Database cross references - Aldh1a1
ExoCarta ExoCarta_24188
Entrez Gene 24188
UniProt P51647  
 Aldh1a1 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Aldh1a1
Molecular Function
    retinal dehydrogenase activity GO:0001758 IMP
    3-chloroallyl aldehyde dehydrogenase activity GO:0004028 TAS
    aldehyde dehydrogenase (NAD) activity GO:0004029 ISO
    identical protein binding GO:0042802 IDA
    benzaldehyde dehydrogenase (NAD+) activity GO:0018479 IDA
Biological Process
    estrous cycle GO:0044849 IEP
    response to oxidative stress GO:0006979 IMP
    retinol metabolic process GO:0042572 ISO
    response to ethanol GO:0045471 IDA
    kidney development GO:0001822 IEP
    retinoic acid metabolic process GO:0042573 ISO
    oxidation-reduction process GO:0055114 IEA
    midgut development GO:0007494 IEP
    embryonic eye morphogenesis GO:0048048 ISO
    9-cis-retinoic acid metabolic process GO:0042905 IDA
    retinoic acid biosynthetic process GO:0002138 IMP
    liver development GO:0001889 IEP
    response to retinoic acid GO:0032526 IEP
    protein homotetramerization GO:0051289 IDA
    response to estradiol GO:0032355 IEP
    positive regulation of apoptotic process GO:0043065 ISO
    9-cis-retinoic acid biosynthetic process GO:0042904 ISO
    response to drug GO:0042493 ISO
    response to organic cyclic compound GO:0014070 IEP
    optic cup morphogenesis involved in camera-type eye development GO:0002072 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified Aldh1a1 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Aldh1a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aldh1a1 is involved
PathwayEvidenceSource
Ethanol oxidation IEA Reactome
RA biosynthesis pathway IEA Reactome





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