Gene description for Aldob
Gene name aldolase B, fructose-bisphosphate
Gene symbol Aldob
Other names/aliases Aldo2
LIV10
Species Rattus norvegicus
 Database cross references - Aldob
ExoCarta ExoCarta_24190
Vesiclepedia VP_24190
Entrez Gene 24190
 Aldob identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Aldob
Molecular Function
    fructose-bisphosphate aldolase activity GO:0004332 IBA
    fructose-bisphosphate aldolase activity GO:0004332 IDA
    fructose-bisphosphate aldolase activity GO:0004332 IEA
    fructose-bisphosphate aldolase activity GO:0004332 ISO
    cytoskeletal protein binding GO:0008092 IEA
    cytoskeletal protein binding GO:0008092 ISO
    phosphatidylcholine binding GO:0031210 IPI
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
    ATPase binding GO:0051117 IEA
    ATPase binding GO:0051117 ISO
    molecular adaptor activity GO:0060090 IEA
    molecular adaptor activity GO:0060090 ISO
    fructose-1-phosphate aldolase activity GO:0061609 IBA
    fructose-1-phosphate aldolase activity GO:0061609 IEA
    fructose-1-phosphate aldolase activity GO:0061609 ISO
    fructose-1-phosphate aldolase activity GO:0061609 ISS
    fructose binding GO:0070061 IEA
    fructose binding GO:0070061 ISO
Biological Process
    liver development GO:0001889 IEP
    fructose metabolic process GO:0006000 ISO
    fructose catabolic process GO:0006001 ISO
    gluconeogenesis GO:0006094 IEA
    glycolytic process GO:0006096 IBA
    glycolytic process GO:0006096 IEA
    glycolytic process GO:0006096 ISO
    glycolytic process GO:0006096 ISS
    NADH oxidation GO:0006116 IEA
    NADH oxidation GO:0006116 ISO
    response to xenobiotic stimulus GO:0009410 IEP
    response to carbohydrate GO:0009743 IEP
    response to fructose GO:0009750 IEP
    response to zinc ion GO:0010043 IDA
    response to organic cyclic compound GO:0014070 IEP
    fructose 1,6-bisphosphate metabolic process GO:0030388 IBA
    fructose 1,6-bisphosphate metabolic process GO:0030388 IEA
    fructose 1,6-bisphosphate metabolic process GO:0030388 ISO
    positive regulation of ATP-dependent activity GO:0032781 ISO
    cellular response to insulin stimulus GO:0032869 IEP
    response to starvation GO:0042594 IEP
    response to amino acid GO:0043200 IEP
    response to peptide hormone GO:0043434 IDA
    response to copper ion GO:0046688 IEP
    response to glucocorticoid GO:0051384 IEP
    response to cAMP GO:0051591 IEP
    fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate GO:0061624 IEA
    fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate GO:0061624 ISO
    vacuolar proton-transporting V-type ATPase complex assembly GO:0070072 IEA
    vacuolar proton-transporting V-type ATPase complex assembly GO:0070072 ISO
    response to interleukin-6 GO:0070741 IEP
    negative regulation of pentose-phosphate shunt GO:1905856 IEA
    negative regulation of pentose-phosphate shunt GO:1905856 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    microtubule organizing center GO:0005815 ISO
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISO
    rough endoplasmic reticulum membrane GO:0030867 IDA
    smooth endoplasmic reticulum membrane GO:0030868 IDA
    centriolar satellite GO:0034451 IEA
    centriolar satellite GO:0034451 ISO
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified Aldob in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Aldob
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aldob is involved
No pathways found





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