Gene description for Asgr1
Gene name asialoglycoprotein receptor 1
Gene symbol Asgr1
Other names/aliases ASGR
RATRHL1
RHL1
Species Rattus norvegicus
 Database cross references - Asgr1
ExoCarta ExoCarta_24210
Vesiclepedia VP_24210
Entrez Gene 24210
UniProt P02706  
 Asgr1 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Asgr1
Molecular Function
    asialoglycoprotein receptor activity GO:0004873 IDA
    D-mannose binding GO:0005537 IBA
    carbohydrate binding GO:0030246 IEA
    pattern recognition receptor activity GO:0038187 IBA
    identical protein binding GO:0042802 ISO
    fucose binding GO:0042806 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    endocytosis GO:0006897 IEA
    immune response GO:0006955 IBA
Subcellular Localization
    external side of plasma membrane GO:0009897 IBA
    membrane GO:0016020 IEA
 Experiment description of studies that identified Asgr1 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Asgr1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Asgr1 is involved
PathwayEvidenceSource
Asparagine N-linked glycosylation IEA Reactome
Metabolism of proteins IEA Reactome
Post-translational protein modification IEA Reactome





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