Gene description for Atp1a2
Gene name	ATPase, Na+/K+ transporting, alpha 2 polypeptide
Gene symbol	Atp1a2
Other names/aliases	RATATPA2
Species	Rattus norvegicus
Database cross references - Atp1a2
ExoCarta	ExoCarta_24212
Vesiclepedia	VP_24212
Entrez Gene	24212
UniProt	P06686
Atp1a2 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells	20124479
Pancreatic cancer cells	20124479

Gene ontology annotations for Atp1a2

Molecular Function     P-type sodium:potassium-exchanging transporter activity GO:0005391 IBA     P-type sodium:potassium-exchanging transporter activity GO:0005391 IDA     P-type sodium:potassium-exchanging transporter activity GO:0005391 ISO     steroid binding GO:0005496 ISO     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     ATP binding GO:0005524 IMP     ATP binding GO:0005524 ISO     P-type potassium transmembrane transporter activity GO:0008556 IEA     ATP hydrolysis activity GO:0016887 IEA     ATP hydrolysis activity GO:0016887 ISO     ATPase-coupled monoatomic cation transmembrane transporter activity GO:0019829 IMP     ATPase-coupled monoatomic cation transmembrane transporter activity GO:0019829 ISO     potassium ion binding GO:0030955 ISO     sodium ion binding GO:0031402 ISO     metal ion binding GO:0046872 IEA     protein heterodimerization activity GO:0046982 IPI     protein-folding chaperone binding GO:0051087 ISO     steroid hormone binding GO:1990239 IDA     steroid hormone binding GO:1990239 ISO Biological Process     neurotransmitter uptake GO:0001504 ISO     neurotransmitter uptake GO:0001504 ISO     behavioral fear response GO:0001662 ISO     regulation of the force of heart contraction GO:0002026 ISO     regulation of respiratory gaseous exchange by nervous system process GO:0002087 ISO     potassium ion transport GO:0006813 IDA     sodium ion transport GO:0006814 IDA     sodium ion transport GO:0006814 IEA     intracellular sodium ion homeostasis GO:0006883 IBA     intracellular sodium ion homeostasis GO:0006883 ISO     regulation of muscle contraction GO:0006937 ISO     regulation of smooth muscle contraction GO:0006940 ISO     regulation of striated muscle contraction GO:0006942 ISO     blood circulation GO:0008015 ISO     regulation of blood pressure GO:0008217 ISO     adult locomotory behavior GO:0008344 ISO     visual learning GO:0008542 ISO     establishment or maintenance of transmembrane electrochemical gradient GO:0010248 IEA     regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 IC     response to auditory stimulus GO:0010996 ISO     energy coupled proton transmembrane transport, against electrochemical gradient GO:0015988 TAS     neuronal action potential propagation GO:0019227 ISO     regulation of vasoconstriction GO:0019229 ISO     L-ascorbic acid metabolic process GO:0019852 ISO     amygdala development GO:0021764 ISO     olfactory cortex development GO:0021989 ISO     intracellular potassium ion homeostasis GO:0030007 IBA     intracellular potassium ion homeostasis GO:0030007 ISO     response to nicotine GO:0035094 IDA     locomotory exploration behavior GO:0035641 ISO     sodium ion transmembrane transport GO:0035725 ISO     response to potassium ion GO:0035864 ISO     sodium ion export across plasma membrane GO:0036376 IBA     sodium ion export across plasma membrane GO:0036376 ISO     locomotion GO:0040011 ISO     fear response GO:0042596 ISO     negative regulation of heart contraction GO:0045822 ISO     negative regulation of striated muscle contraction GO:0045988 ISO     ATP metabolic process GO:0046034 ISO     negative regulation of cytosolic calcium ion concentration GO:0051481 ISO     membrane depolarization GO:0051899 ISO     relaxation of cardiac muscle GO:0055119 IC     cardiac muscle contraction GO:0060048 IC     cellular response to mechanical stimulus GO:0071260 IDA     cellular response to mechanical stimulus GO:0071260 IEP     cellular response to steroid hormone stimulus GO:0071383 IMP     cellular response to steroid hormone stimulus GO:0071383 ISO     potassium ion transmembrane transport GO:0071805 IEA     potassium ion transmembrane transport GO:0071805 ISO     regulation of cardiac muscle cell contraction GO:0086004 IMP     monoatomic cation transmembrane transport GO:0098655 ISO     proton transmembrane transport GO:1902600 IBA     proton transmembrane transport GO:1902600 IMP     negative regulation of calcium ion transmembrane transport GO:1903170 IMP     response to glycoside GO:1903416 IMP     response to glycoside GO:1903416 ISO     potassium ion import across plasma membrane GO:1990573 IBA     potassium ion import across plasma membrane GO:1990573 ISO Subcellular Localization     cytoplasm GO:0005737 ISO     endosome GO:0005768 IDA     endoplasmic reticulum GO:0005783 ISO     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IEA     plasma membrane GO:0005886 ISO     plasma membrane GO:0005886 ISO     sodium:potassium-exchanging ATPase complex GO:0005890 IBA     sodium:potassium-exchanging ATPase complex GO:0005890 IDA     sodium:potassium-exchanging ATPase complex GO:0005890 ISO     caveola GO:0005901 IDA     cell surface GO:0009986 ISO     intercalated disc GO:0014704 IDA     membrane GO:0016020 IDA     membrane GO:0016020 ISO     T-tubule GO:0030315 IDA     T-tubule GO:0030315 ISO     organelle membrane GO:0031090 ISO     protein-containing complex GO:0032991 ISO     sarcolemma GO:0042383 IDA     sarcolemma GO:0042383 ISO     cell projection GO:0042995 IBA     cell projection GO:0042995 ISO     neuronal cell body GO:0043025 ISO     dendritic spine GO:0043197 IDA