Gene description for Atp1a3
Gene name ATPase, Na+/K+ transporting, alpha 3 polypeptide
Gene symbol Atp1a3
Other names/aliases Atpa1a3
Species Rattus norvegicus
 Database cross references - Atp1a3
ExoCarta ExoCarta_24213
Entrez Gene 24213
UniProt P06687  
 Atp1a3 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Atp1a3
Molecular Function
    heparan sulfate proteoglycan binding GO:0043395 ISO
    sodium:potassium-exchanging ATPase activity GO:0005391 ISS
    metal ion binding GO:0046872 IEA
    sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential GO:0086037 ISO
    chaperone binding GO:0051087 ISO
    protein binding GO:0005515 IPI
    cation-transporting ATPase activity GO:0019829 TAS
    ATP binding GO:0005524 TAS
    D1 dopamine receptor binding GO:0031748 IPI
Biological Process
    cellular sodium ion homeostasis GO:0006883 ISO
    visual learning GO:0008542 ISO
    regulation of cardiac muscle cell membrane potential GO:0086036 ISO
    sodium ion transmembrane transport GO:0035725 ISO
    potassium ion import GO:0010107 ISO
    potassium ion transport GO:0006813 IDA
    response to drug GO:0042493 ISO
    ATP hydrolysis coupled proton transport GO:0015991 TAS
    metabolic process GO:0008152 IEA
    sodium ion transport GO:0006814 IDA
    cellular potassium ion homeostasis GO:0030007 ISO
    sodium ion export from cell GO:0036376 ISO
    ionotropic glutamate receptor signaling pathway GO:0035235 ISO
    cardiac muscle contraction GO:0060048 ISO
    adult locomotory behavior GO:0008344 ISO
    potassium ion transmembrane transport GO:0071805 ISO
    memory GO:0007613 ISO
Subcellular Localization
    vesicle GO:0031982 IEA
    axon GO:0030424 IDA
    extracellular vesicle GO:1903561 ISO
    myelin sheath GO:0043209 ISO
    Golgi apparatus GO:0005794 ISS
    sodium:potassium-exchanging ATPase complex GO:0005890 ISO
    sarcolemma GO:0042383 ISO
    dendritic spine head GO:0044327 IDA
    endoplasmic reticulum GO:0005783 ISS
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
    dendritic spine neck GO:0044326 IDA
    plasma membrane GO:0005886 TAS
    synapse GO:0045202 IDA
 Experiment description of studies that identified Atp1a3 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Atp1a3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp1a3 is involved
PathwayEvidenceSource
Ion transport by P-type ATPases IEA Reactome





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