Gene description for Fbp1
Gene name fructose-1,6-bisphosphatase 1
Gene symbol Fbp1
Other names/aliases Fdp
Species Rattus norvegicus
 Database cross references - Fbp1
ExoCarta ExoCarta_24362
Entrez Gene 24362
UniProt P19112  
 Fbp1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
Urine 20535238    
 Gene ontology annotations for Fbp1
Molecular Function
    metal ion binding GO:0046872 ISS
    fructose 1,6-bisphosphate 1-phosphatase activity GO:0042132 TAS
    monosaccharide binding GO:0048029 IDA
    AMP binding GO:0016208 ISS
    identical protein binding GO:0042802 ISO
Biological Process
    cellular response to drug GO:0035690 ISS
    cellular response to magnesium ion GO:0071286 ISS
    negative regulation of Ras protein signal transduction GO:0046580 ISS
    cellular response to insulin stimulus GO:0032869 IEP
    carbohydrate metabolic process GO:0005975 IEA
    negative regulation of cell growth GO:0030308 ISS
    fructose 6-phosphate metabolic process GO:0006002 ISS
    regulation of gluconeogenesis GO:0006111 ISS
    dephosphorylation GO:0016311 ISS
    protein homotetramerization GO:0051289 ISS
    gluconeogenesis GO:0006094 ISO
    negative regulation of glycolytic process GO:0045820 ISS
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Fbp1 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Fbp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fbp1 is involved
No pathways found





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