Gene description for Gfap
Gene name glial fibrillary acidic protein
Gene symbol Gfap
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Gfap
ExoCarta ExoCarta_24387
Entrez Gene 24387
UniProt P47819  
 Gfap identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Gfap
Molecular Function
    structural constituent of cytoskeleton GO:0005200 IDA
    integrin binding GO:0005178 IDA
    kinase binding GO:0019900 IPI
    structural molecule activity GO:0005198 ISO
Biological Process
    intermediate filament organization GO:0045109 ISO
    response to wounding GO:0009611 IDA
    long-term synaptic potentiation GO:0060291 ISO
    neuron projection regeneration GO:0031102 ISO
    positive regulation of Schwann cell proliferation GO:0010625 ISO
    extracellular matrix organization GO:0030198 ISO
    positive regulation of glial cell proliferation GO:0060252 IMP
    Bergmann glial cell differentiation GO:0060020 ISO
    intermediate filament-based process GO:0045103 ISO
    regulation of neurotransmitter uptake GO:0051580 ISO
    astrocyte development GO:0014002 ISO
    negative regulation of neuron projection development GO:0010977 ISO
Subcellular Localization
    myelin sheath GO:0043209 ISO
    astrocyte end-foot GO:0097450 ISO
    cytoplasm GO:0005737 ISO
    glial cell projection GO:0097386 ISO
    membrane GO:0016020 ISO
    astrocyte projection GO:0097449 ISO
    intermediate filament GO:0005882 TAS
    cell projection GO:0042995 ISO
    cell body GO:0044297 ISO
 Experiment description of studies that identified Gfap in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Gfap
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gfap is involved
PathwayEvidenceSource
Nuclear signaling by ERBB4 IEA Reactome





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