Gene description for Gfap
Gene name glial fibrillary acidic protein
Gene symbol Gfap
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Gfap
ExoCarta ExoCarta_24387
Vesiclepedia VP_24387
Entrez Gene 24387
UniProt P47819  
 Gfap identified in sEVs derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Gfap
Molecular Function
    integrin binding GO:0005178 IDA
    structural constituent of cytoskeleton GO:0005200 IBA
    structural constituent of cytoskeleton GO:0005200 IDA
    structural constituent of cytoskeleton GO:0005200 ISO
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 IPI
    identical protein binding GO:0042802 ISO
Biological Process
    intracellular protein transport GO:0006886 ISO
    gene expression GO:0010467 ISO
    positive regulation of Schwann cell proliferation GO:0010625 ISO
    negative regulation of neuron projection development GO:0010977 ISO
    astrocyte development GO:0014002 ISO
    Schwann cell proliferation GO:0014010 ISO
    extracellular matrix organization GO:0030198 ISO
    neuron projection regeneration GO:0031102 ISO
    neuron projection development GO:0031175 ISO
    intermediate filament-based process GO:0045103 ISO
    intermediate filament organization GO:0045109 IBA
    intermediate filament organization GO:0045109 ISO
    intermediate filament organization GO:0045109 ISO
    intermediate filament organization GO:0045109 ISS
    regulation of neurotransmitter uptake GO:0051580 ISO
    Bergmann glial cell differentiation GO:0060020 ISO
    positive regulation of glial cell proliferation GO:0060252 IMP
    long-term synaptic potentiation GO:0060291 ISO
    D-aspartate import across plasma membrane GO:0070779 ISO
    regulation of chaperone-mediated autophagy GO:1904714 IBA
    regulation of chaperone-mediated autophagy GO:1904714 IMP
    regulation of chaperone-mediated autophagy GO:1904714 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    lysosome GO:0005764 ISO
    lysosomal membrane GO:0005765 TAS
    cytoskeleton GO:0005856 ISO
    intermediate filament GO:0005882 IBA
    intermediate filament GO:0005882 IEA
    intermediate filament GO:0005882 ISO
    membrane GO:0016020 ISO
    cell projection GO:0042995 IBA
    cell projection GO:0042995 ISO
    cell body GO:0044297 ISO
    intermediate filament cytoskeleton GO:0045111 ISO
    glial cell projection GO:0097386 ISO
    astrocyte projection GO:0097449 IDA
    astrocyte projection GO:0097449 ISO
    astrocyte end-foot GO:0097450 ISO
    cytoplasmic side of lysosomal membrane GO:0098574 IDA
 Experiment description of studies that identified Gfap in sEVs
1
Experiment ID 225
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors "Lee JE, Moon PG, Lee IK, Baek MC"
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Gfap
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
2 Rad23b  
Affinity Capture-MS Rattus norvegicus
3 Itm2b 290364
Affinity Capture-MS Rattus norvegicus
View the network image/svg+xml
 Pathways in which Gfap is involved
No pathways found





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