Gene description for Gpx1
Gene name	glutathione peroxidase 1
Gene symbol	Gpx1
Other names/aliases	GSHPx GSHPx-1
Species	Rattus norvegicus
Database cross references - Gpx1
ExoCarta	ExoCarta_24404
Vesiclepedia	VP_24404
Entrez Gene	24404
UniProt	P04041
Gpx1 identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Gpx1

Molecular Function     peroxidase activity GO:0004601 ISO     glutathione peroxidase activity GO:0004602 IBA     glutathione peroxidase activity GO:0004602 IDA     glutathione peroxidase activity GO:0004602 IEA     glutathione peroxidase activity GO:0004602 ISO     SH3 domain binding GO:0017124 IEA     SH3 domain binding GO:0017124 ISO     phospholipid-hydroperoxide glutathione peroxidase activity GO:0047066 IEA     phospholipid-hydroperoxide glutathione peroxidase activity GO:0047066 ISO     phospholipid-hydroperoxide glutathione peroxidase activity GO:0047066 ISS Biological Process     response to reactive oxygen species GO:0000302 ISO     temperature homeostasis GO:0001659 IEA     temperature homeostasis GO:0001659 ISO     endothelial cell development GO:0001885 IEA     endothelial cell development GO:0001885 ISO     negative regulation of inflammatory response to antigenic stimulus GO:0002862 IEA     negative regulation of inflammatory response to antigenic stimulus GO:0002862 ISO     lipid metabolic process GO:0006629 ISO     triglyceride metabolic process GO:0006641 IEA     triglyceride metabolic process GO:0006641 ISO     glutathione metabolic process GO:0006749 IBA     glutathione metabolic process GO:0006749 IEA     glutathione metabolic process GO:0006749 ISO     apoptotic process GO:0006915 ISO     response to oxidative stress GO:0006979 ISO     sensory perception of sound GO:0007605 IEA     sensory perception of sound GO:0007605 ISO     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 IEA     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 ISO     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 ISO     response to xenobiotic stimulus GO:0009410 IEA     response to xenobiotic stimulus GO:0009410 ISO     response to symbiotic bacterium GO:0009609 IEA     response to symbiotic bacterium GO:0009609 ISO     response to wounding GO:0009611 ISO     response to toxic substance GO:0009636 ISO     UV protection GO:0009650 IEA     UV protection GO:0009650 ISO     response to hormone GO:0009725 IEP     response to glucose GO:0009749 IEP     response to selenium ion GO:0010269 IBA     response to selenium ion GO:0010269 IEA     response to selenium ion GO:0010269 IEP     response to selenium ion GO:0010269 ISO     response to gamma radiation GO:0010332 IEA     response to gamma radiation GO:0010332 ISO     response to organic cyclic compound GO:0014070 IEP     myotube differentiation GO:0014902 ISO     protein oxidation GO:0018158 ISO     arachidonate metabolic process GO:0019369 IEA     arachidonate metabolic process GO:0019369 ISO     arachidonate metabolic process GO:0019369 ISS     lipoxygenase pathway GO:0019372 IEA     lipoxygenase pathway GO:0019372 ISO     lipoxygenase pathway GO:0019372 ISS     response to estradiol GO:0032355 IEP     response to lipopolysaccharide GO:0032496 IEA     response to lipopolysaccharide GO:0032496 ISO     response to hydroperoxide GO:0033194 IEA     response to hydroperoxide GO:0033194 ISO     response to vitamin E GO:0033197 IEP     regulation of mammary gland epithelial cell proliferation GO:0033599 IEA     regulation of mammary gland epithelial cell proliferation GO:0033599 ISO     response to nicotine GO:0035094 IEP     epigenetic regulation of gene expression GO:0040029 IEA     epigenetic regulation of gene expression GO:0040029 ISO     vasodilation GO:0042311 IEA     vasodilation GO:0042311 ISO     response to hydrogen peroxide GO:0042542 IBA     response to hydrogen peroxide GO:0042542 IEA     response to hydrogen peroxide GO:0042542 ISO     response to hydrogen peroxide GO:0042542 ISO     hydrogen peroxide catabolic process GO:0042744 IBA     hydrogen peroxide catabolic process GO:0042744 IEA     hydrogen peroxide catabolic process GO:0042744 ISO     hydrogen peroxide catabolic process GO:0042744 ISO     skeletal muscle tissue regeneration GO:0043403 IEA     skeletal muscle tissue regeneration GO:0043403 ISO     blood vessel endothelial cell migration GO:0043534 IEA     blood vessel endothelial cell migration GO:0043534 ISO     fat cell differentiation GO:0045444 IEA     fat cell differentiation GO:0045444 ISO     myoblast differentiation GO:0045445 IEA     myoblast differentiation GO:0045445 ISO     cell redox homeostasis GO:0045454 IEA     cell redox homeostasis GO:0045454 ISO     fibroblast proliferation GO:0048144 IEA     fibroblast proliferation GO:0048144 ISO     skeletal muscle fiber development GO:0048741 IEA     skeletal muscle fiber development GO:0048741 ISO     neuron apoptotic process GO:0051402 IEA     neuron apoptotic process GO:0051402 ISO     myoblast proliferation GO:0051450 IEA     myoblast proliferation GO:0051450 ISO     response to folic acid GO:0051593 IEP     biological process involved in interaction with symbiont GO:0051702 IEA     biological process involved in interaction with symbiont GO:0051702 ISO     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 IEA     positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051897 ISO     heart contraction GO:0060047 IEA     heart contraction GO:0060047 ISO     heart contraction GO:0060047 ISO     angiogenesis involved in wound healing GO:0060055 IEA     angiogenesis involved in wound healing GO:0060055 ISO     regulation of proteasomal protein catabolic process GO:0061136 IEA     regulation of proteasomal protein catabolic process GO:0061136 ISO     cellular response to glucose stimulus GO:0071333 IDA     negative regulation of release of cytochrome c from mitochondria GO:0090201 IEA     negative regulation of release of cytochrome c from mitochondria GO:0090201 ISO     cellular oxidant detoxification GO:0098869 IEA     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IEA     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 ISO     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 IEA     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 ISO Subcellular Localization     cytoplasm GO:0005737 ISO     mitochondrion GO:0005739 IBA     mitochondrion GO:0005739 IEA     mitochondrion GO:0005739 ISO     cytosol GO:0005829 IBA     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     cytosol GO:0005829 ISS     Lewy body GO:0097413 IEA     Lewy body GO:0097413 ISO