Gene description for Hmgcs2
Gene name 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Gene symbol Hmgcs2
Other names/aliases Hmgcs1
Mt3h3mg
Species Rattus norvegicus
 Database cross references - Hmgcs2
ExoCarta ExoCarta_24450
Entrez Gene 24450
 Hmgcs2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Hmgcs2
Molecular Function
    hydroxymethylglutaryl-CoA synthase activity GO:0004421 TAS
Biological Process
    ketone body biosynthetic process GO:0046951 TAS
    adipose tissue development GO:0060612 IEP
    response to temperature stimulus GO:0009266 IEP
    multicellular organismal response to stress GO:0033555 IEP
    response to insulin GO:0032868 IEP
    kidney development GO:0001822 IEP
    response to growth hormone GO:0060416 IEP
    brain development GO:0007420 IEP
    liver development GO:0001889 IEP
    lung development GO:0030324 IEP
    response to glucagon GO:0033762 IEP
    cellular response to lipopolysaccharide GO:0071222 IEP
    response to fatty acid GO:0070542 IEP
    isoprenoid biosynthetic process GO:0008299 IEA
    response to starvation GO:0042594 IEP
    response to ethanol GO:0045471 IEP
    response to testosterone GO:0033574 IEP
    cellular response to hormone stimulus GO:0032870 IEP
    response to drug GO:0042493 IEP
    cellular response to insulin stimulus GO:0032869 IEP
    response to prostaglandin F GO:0034696 IEP
    cholesterol biosynthetic process GO:0006695 IEA
    response to bacterium GO:0009617 IEP
    response to nutrient GO:0007584 IEP
    cellular response to amino acid stimulus GO:0071230 IEP
    response to triglyceride GO:0034014 IEP
    cellular response to glucocorticoid stimulus GO:0071385 IEP
    midgut development GO:0007494 IEP
    response to linoleic acid GO:0070543 IEP
    response to glucocorticoid GO:0051384 IEP
    response to organic cyclic compound GO:0014070 IEP
    response to metal ion GO:0010038 IEP
    response to monosaccharide GO:0034284 IEP
    cellular response to fatty acid GO:0071398 IEP
    cellular response to organic cyclic compound GO:0071407 IEP
    response to cAMP GO:0051591 IEP
    response to peptide hormone GO:0043434 IEP
Subcellular Localization
    mitochondrion GO:0005739 TAS
    mitochondrial inner membrane GO:0005743 ISO
    mitochondrial matrix GO:0005759 IDA
 Experiment description of studies that identified Hmgcs2 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Hmgcs2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Hmgcs2 is involved
No pathways found





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