Gene description for Idh1
Gene name isocitrate dehydrogenase 1 (NADP+), soluble
Gene symbol Idh1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Idh1
ExoCarta ExoCarta_24479
Entrez Gene 24479
UniProt P41562  
 Idh1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Idh1
Molecular Function
    magnesium ion binding GO:0000287 ISS
    isocitrate dehydrogenase (NADP+) activity GO:0004450 TAS
    NAD binding GO:0051287 IEA
    receptor binding GO:0005102 ISO
    protein homodimerization activity GO:0042803 ISO
    NADP binding GO:0050661 IDA
Biological Process
    tricarboxylic acid cycle GO:0006099 IEA
    regulation of phospholipid biosynthetic process GO:0071071 ISO
    regulation of phospholipid catabolic process GO:0060696 ISO
    glyoxylate cycle GO:0006097 IEA
    response to oxidative stress GO:0006979 ISO
    female gonad development GO:0008585 IEP
    response to steroid hormone GO:0048545 IDA
    response to organic cyclic compound GO:0014070 IDA
    glutathione metabolic process GO:0006749 ISO
    2-oxoglutarate metabolic process GO:0006103 ISS
    isocitrate metabolic process GO:0006102 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISO
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 ISO
    extracellular exosome GO:0070062 ISO
    peroxisome GO:0005777 ISO
 Experiment description of studies that identified Idh1 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Idh1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Idh1 is involved
PathwayEvidenceSource
NADPH regeneration IEA Reactome





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