Gene description for Lpl
Gene name	lipoprotein lipase
Gene symbol	Lpl
Other names/aliases	-
Species	Rattus norvegicus
Database cross references - Lpl
ExoCarta	ExoCarta_24539
Vesiclepedia	VP_24539
Entrez Gene	24539
UniProt	Q06000
Lpl identified in sEVs derived from the following tissue/cell type
Adipocytes	25998041

Gene ontology annotations for Lpl

Molecular Function     lipoprotein lipase activity GO:0004465 IBA     lipoprotein lipase activity GO:0004465 IDA     lipoprotein lipase activity GO:0004465 IEA     lipoprotein lipase activity GO:0004465 ISO     triacylglycerol lipase activity GO:0004806 ISO     signaling receptor binding GO:0005102 IEA     signaling receptor binding GO:0005102 ISO     calcium ion binding GO:0005509 IEA     calcium ion binding GO:0005509 ISO     heparin binding GO:0008201 IEA     heparin binding GO:0008201 ISO     heparin binding GO:0008201 ISS     phospholipase A1 activity GO:0008970 IBA     phospholipase A1 activity GO:0008970 IEA     phospholipase A1 activity GO:0008970 ISO     phospholipase A1 activity GO:0008970 ISS     triglyceride binding GO:0017129 IDA     apolipoprotein binding GO:0034185 IBA     apolipoprotein binding GO:0034185 IEA     apolipoprotein binding GO:0034185 ISO     protein homodimerization activity GO:0042803 IEA     protein homodimerization activity GO:0042803 ISO     heparan sulfate proteoglycan binding GO:0043395 IEA     heparan sulfate proteoglycan binding GO:0043395 ISO     heparan sulfate proteoglycan binding GO:0043395 ISS     phosphatidylserine 1-acylhydrolase activity GO:0052739 IEA     lipoprotein particle binding GO:0071813 IEA     lipoprotein particle binding GO:0071813 ISO     lipoprotein particle binding GO:0071813 ISS Biological Process     fatty acid metabolic process GO:0006631 ISO     fatty acid metabolic process GO:0006631 ISS     fatty acid biosynthetic process GO:0006633 IBA     fatty acid biosynthetic process GO:0006633 IEA     fatty acid biosynthetic process GO:0006633 ISO     response to xenobiotic stimulus GO:0009410 IEP     response to bacterium GO:0009617 IEA     response to bacterium GO:0009617 ISO     positive regulation of macrophage derived foam cell differentiation GO:0010744 IEA     positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO     positive regulation of cholesterol storage GO:0010886 IEA     positive regulation of cholesterol storage GO:0010886 ISO     positive regulation of sequestering of triglyceride GO:0010890 IEA     positive regulation of sequestering of triglyceride GO:0010890 ISO     lipid catabolic process GO:0016042 IDA     triglyceride biosynthetic process GO:0019432 IMP     triglyceride catabolic process GO:0019433 IBA     triglyceride catabolic process GO:0019433 IEA     triglyceride catabolic process GO:0019433 ISO     triglyceride catabolic process GO:0019433 ISS     cellular response to nutrient GO:0031670 IEA     cellular response to nutrient GO:0031670 ISO     positive regulation of chemokine production GO:0032722 ISO     positive regulation of interleukin-1 beta production GO:0032731 IEA     positive regulation of interleukin-1 beta production GO:0032731 ISO     positive regulation of interleukin-6 production GO:0032755 IEA     positive regulation of interleukin-6 production GO:0032755 ISO     positive regulation of tumor necrosis factor production GO:0032760 IEA     positive regulation of tumor necrosis factor production GO:0032760 ISO     chylomicron remodeling GO:0034371 IEA     chylomicron remodeling GO:0034371 ISO     chylomicron remodeling GO:0034371 ISS     very-low-density lipoprotein particle remodeling GO:0034372 IBA     very-low-density lipoprotein particle remodeling GO:0034372 IEA     very-low-density lipoprotein particle remodeling GO:0034372 ISO     high-density lipoprotein particle remodeling GO:0034375 IBA     cholesterol homeostasis GO:0042632 IBA     cholesterol homeostasis GO:0042632 IEA     cholesterol homeostasis GO:0042632 ISO     positive regulation of fat cell differentiation GO:0045600 IEA     positive regulation of fat cell differentiation GO:0045600 ISO     positive regulation of inflammatory response GO:0050729 IEA     positive regulation of inflammatory response GO:0050729 ISO     low-density lipoprotein particle mediated signaling GO:0055096 IEA     low-density lipoprotein particle mediated signaling GO:0055096 ISO     triglyceride homeostasis GO:0070328 IEA     triglyceride homeostasis GO:0070328 ISO     cellular response to fatty acid GO:0071398 IEA     cellular response to fatty acid GO:0071398 ISO     negative regulation of cellular response to insulin stimulus GO:1900077 IMP     positive regulation of adipose tissue development GO:1904179 IEA     positive regulation of adipose tissue development GO:1904179 ISO     positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 IEA     positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 ISO Subcellular Localization     extracellular space GO:0005615 IBA     extracellular space GO:0005615 IDA     extracellular space GO:0005615 ISO     extracellular space GO:0005615 ISS     plasma membrane GO:0005886 IEA     cell surface GO:0009986 IEA     cell surface GO:0009986 ISO     very-low-density lipoprotein particle GO:0034361 IEA     chylomicron GO:0042627 IEA     catalytic complex GO:1902494 IEA     catalytic complex GO:1902494 ISO