Gene description for Lpl
Gene name lipoprotein lipase
Gene symbol Lpl
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lpl
ExoCarta ExoCarta_24539
Entrez Gene 24539
UniProt Q06000  
 Lpl identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Lpl
Molecular Function
    apolipoprotein binding GO:0034185 ISO
    triglyceride binding GO:0017129 IDA
    heparin binding GO:0008201 ISO
    lipoprotein lipase activity GO:0004465 ISO
    receptor binding GO:0005102 ISO
    triglyceride lipase activity GO:0004806 ISO
Biological Process
    fatty acid biosynthetic process GO:0006633 ISO
    triglyceride biosynthetic process GO:0019432 IMP
    response to drug GO:0042493 IEP
    positive regulation of sequestering of triglyceride GO:0010890 ISO
    positive regulation of macrophage derived foam cell differentiation GO:0010744 ISO
    triglyceride catabolic process GO:0019433 ISO
    positive regulation of cholesterol storage GO:0010886 ISO
    very-low-density lipoprotein particle remodeling GO:0034372 ISO
    lipid catabolic process GO:0016042 IDA
    response to cold GO:0009409 IEP
    triglyceride homeostasis GO:0070328 ISO
Subcellular Localization
    chylomicron GO:0042627 IEA
    very-low-density lipoprotein particle GO:0034361 IEA
    anchored component of membrane GO:0031225 IEA
    extracellular exosome GO:0070062 ISO
    cell surface GO:0009986 ISO
    extracellular matrix GO:0031012 IDA
    extracellular space GO:0005615 ISO
    plasma membrane GO:0005886 IEA
 Experiment description of studies that identified Lpl in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Lpl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lpl is involved
PathwayEvidenceSource
Chylomicron-mediated lipid transport IEA Reactome
Retinoid metabolism and transport IEA Reactome





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