Gene description for Mme
Gene name membrane metallo-endopeptidase
Gene symbol Mme
Other names/aliases CD10
Nep
SFE
Species Rattus norvegicus
 Database cross references - Mme
ExoCarta ExoCarta_24590
Entrez Gene 24590
UniProt P07861  
 Mme identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Urine 20535238    
 Gene ontology annotations for Mme
Molecular Function
    peptidase activity GO:0008233 ISO
    metalloendopeptidase activity GO:0004222 ISS
    peptide binding GO:0042277 IMP
    exopeptidase activity GO:0008238 ISO
    endopeptidase activity GO:0004175 ISO
    zinc ion binding GO:0008270 ISS
Biological Process
    beta-amyloid metabolic process GO:0050435 ISS
    cellular response to UV-B GO:0071493 ISS
    kidney development GO:0001822 ISS
    creatinine metabolic process GO:0046449 ISS
    cellular response to UV-A GO:0071492 ISS
    peptide metabolic process GO:0006518 IMP
    replicative senescence GO:0090399 ISS
    sensory perception of pain GO:0019233 ISS
    proteolysis GO:0006508 ISO
    cellular response to cytokine stimulus GO:0071345 ISS
Subcellular Localization
    synaptic vesicle GO:0008021 ISS
    brush border GO:0005903 ISS
    axon GO:0030424 ISS
    neuron projection terminus GO:0044306 ISS
    cytoplasm GO:0005737 ISS
    membrane GO:0016020 ISO
    synapse GO:0045202 ISS
    plasma membrane GO:0005886 ISS
    integral component of membrane GO:0016021 IEA
    focal adhesion GO:0005925 ISO
    extracellular exosome GO:0070062 ISO
    dendrite GO:0030425 ISS
 Experiment description of studies that identified Mme in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 192
ISEV standards
CEM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
CD63|CD81|FLOT
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Mme
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mme is involved
PathwayEvidenceSource
Metabolism of Angiotensinogen to Angiotensins IEA Reactome





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