Gene description for Scn3b
Gene name sodium channel, voltage-gated, type III, beta subunit
Gene symbol Scn3b
Other names/aliases Scnb3
Species Rattus norvegicus
 Database cross references - Scn3b
ExoCarta ExoCarta_245956
Entrez Gene 245956
UniProt Q9JK00  
 Scn3b identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Scn3b
Molecular Function
    voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 ISO
    ion channel binding GO:0044325 ISO
    sodium channel regulator activity GO:0017080 ISO
    molecular_function GO:0003674 ND
Biological Process
    SA node cell to atrial cardiac muscle cell communication GO:0086070 IEA
    SA node cell action potential GO:0086015 ISO
    membrane depolarization GO:0051899 ISO
    positive regulation of sodium ion transport GO:0010765 ISO
    membrane depolarization during cardiac muscle cell action potential GO:0086012 ISO
    regulation of sodium ion transmembrane transporter activity GO:2000649 ISO
    atrial cardiac muscle cell action potential GO:0086014 ISO
    cardiac muscle cell action potential involved in contraction GO:0086002 ISO
    membrane depolarization during action potential GO:0086010 ISO
    positive regulation of heart rate GO:0010460 ISO
    sodium ion transport GO:0006814 IDA
    sensory perception of pain GO:0019233 IEP
    regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 ISO
    nervous system development GO:0007399 IEP
    cardiac conduction GO:0061337 ISO
    ventricular cardiac muscle cell action potential GO:0086005 ISO
    regulation of heart rate by cardiac conduction GO:0086091 ISO
    regulation of ion transmembrane transport GO:0034765 ISO
    cardiac muscle contraction GO:0060048 ISO
    sodium ion transmembrane transport GO:0035725 ISO
    regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 ISO
    protein localization to plasma membrane GO:0072659 ISO
Subcellular Localization
    Z disc GO:0030018 ISO
    voltage-gated sodium channel complex GO:0001518 ISO
    integral component of membrane GO:0016021 IDA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified Scn3b in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Scn3b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Scn3b is involved
PathwayEvidenceSource
Interaction between L1 and Ankyrins IEA Reactome





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