Gene description for Lmbrd1
Gene name LMBR1 domain containing 1
Gene symbol Lmbrd1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Lmbrd1
ExoCarta ExoCarta_246046
Entrez Gene 246046
UniProt Q6AZ61  
 Lmbrd1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Lmbrd1
Molecular Function
    cobalamin binding GO:0031419 IEA
    insulin receptor binding GO:0005158 ISO
Biological Process
    insulin receptor internalization GO:0038016 ISO
    negative regulation of protein kinase B signaling GO:0051898 ISO
    regulation of MAPK cascade GO:0043408 ISO
    negative regulation of insulin receptor signaling pathway GO:0046627 ISO
    negative regulation of glucose import GO:0046325 ISO
Subcellular Localization
    lysosome GO:0005764 ISO
    clathrin-coated endocytic vesicle GO:0045334 ISO
    lysosomal membrane GO:0005765 IEA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 ISO
    membrane GO:0016020 ISO
 Experiment description of studies that identified Lmbrd1 in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 99
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [QSTAR]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Lmbrd1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lmbrd1 is involved
PathwayEvidenceSource
Cobalamin (Cbl, vitamin B12) transport and metabolism IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here