Gene description for S100a4
Gene name S100 calcium-binding protein A4
Gene symbol S100a4
Other names/aliases 18A2
42A
CAPL
MTS1
P9ka
PEL98
RNP9KA
Species Rattus norvegicus
 Database cross references - S100a4
ExoCarta ExoCarta_24615
Vesiclepedia VP_24615
Entrez Gene 24615
UniProt P05942  
 S100a4 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for S100a4
Molecular Function
    actin binding GO:0003779 IDA
    calcium ion binding GO:0005509 IBA
    calcium ion binding GO:0005509 IDA
    calcium ion binding GO:0005509 ISO
    calcium ion binding GO:0005509 TAS
    protein binding GO:0005515 IPI
    chemoattractant activity GO:0042056 ISO
    identical protein binding GO:0042802 ISO
    protein-containing complex binding GO:0044877 TAS
    transition metal ion binding GO:0046914 IEA
    calcium-dependent protein binding GO:0048306 IBA
    calcium-dependent protein binding GO:0048306 IDA
    calcium-dependent protein binding GO:0048306 IMP
    RAGE receptor binding GO:0050786 IBA
    RAGE receptor binding GO:0050786 ISO
Biological Process
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 ISO
    positive chemotaxis GO:0050918 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    perinuclear region of cytoplasm GO:0048471 IBA
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified S100a4 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for S100a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which S100a4 is involved
No pathways found





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