Gene description for S100a4
Gene name S100 calcium-binding protein A4
Gene symbol S100a4
Other names/aliases 18A2
42A
CAPL
MTS1
P9ka
PEL98
RNP9KA
Species Rattus norvegicus
 Database cross references - S100a4
ExoCarta ExoCarta_24615
Entrez Gene 24615
UniProt P05942  
 S100a4 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for S100a4
Molecular Function
    calcium-dependent protein binding GO:0048306 IMP
    protein heterodimerization activity GO:0046982 TAS
    RAGE receptor binding GO:0050786 ISO
    poly(A) RNA binding GO:0044822 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 TAS
    actin binding GO:0003779 IDA
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 TAS
Biological Process
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISO
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISO
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 ISO
    neuron projection GO:0043005 IDA
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified S100a4 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for S100a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which S100a4 is involved
No pathways found





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