Gene description for Kcnc2
Gene name potassium channel, voltage gated Shaw-related subfamily C, member 2
Gene symbol Kcnc2
Other names/aliases KShIIIA
Kv3.2
Species Rattus norvegicus
 Database cross references - Kcnc2
ExoCarta ExoCarta_246153
Entrez Gene 246153
UniProt P22462  
 Kcnc2 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Kcnc2
Molecular Function
    protein binding GO:0005515 IPI
    delayed rectifier potassium channel activity GO:0005251 IDA
    ion channel binding GO:0044325 ISO
    voltage-gated potassium channel activity GO:0005249 IDA
Biological Process
    response to light intensity GO:0009642 IEP
    response to ethanol GO:0045471 IEP
    cellular response to nitric oxide GO:0071732 IDA
    response to amine GO:0014075 IEP
    action potential GO:0001508 ISO
    response to organic cyclic compound GO:0014070 IEP
    globus pallidus development GO:0021759 IEP
    ion transmembrane transport GO:0034220 IDA
    positive regulation of potassium ion transmembrane transport GO:1901381 IDA
    response to magnesium ion GO:0032026 IEP
    response to nerve growth factor GO:1990089 IEP
    potassium ion transmembrane transport GO:0071805 IDA
    protein heterooligomerization GO:0051291 IDA
    cellular response to toxic substance GO:0097237 IMP
    cellular response to ammonium ion GO:0071242 IEP
    protein homooligomerization GO:0051260 IDA
    response to toxic substance GO:0009636 IEP
    nitric oxide-cGMP-mediated signaling pathway GO:0038060 IDA
Subcellular Localization
    postsynaptic membrane GO:0045211 ISS
    axon GO:0030424 IDA
    presynaptic membrane GO:0042734 ISS
    vesicle GO:0031982 IDA
    intracellular GO:0005622 IDA
    neuronal cell body membrane GO:0032809 ISO
    neuronal cell body GO:0043025 IDA
    apical plasma membrane GO:0016324 IDA
    voltage-gated potassium channel complex GO:0008076 IDA
    axolemma GO:0030673 IDA
    dendrite GO:0030425 ISO
    terminal bouton GO:0043195 IDA
    perikaryon GO:0043204 ISS
    membrane GO:0016020 ISO
    plasma membrane GO:0005886 IDA
    basolateral plasma membrane GO:0016323 IDA
    integral component of plasma membrane GO:0005887 IDA
    synapse GO:0045202 IDA
 Experiment description of studies that identified Kcnc2 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Kcnc2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Kcnc2 is involved
PathwayEvidenceSource
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion IEA Reactome
Voltage gated Potassium channels IEA Reactome





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