Gene description for Pah
Gene name phenylalanine hydroxylase
Gene symbol Pah
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pah
ExoCarta ExoCarta_24616
Entrez Gene 24616
 Pah identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Pah
Molecular Function
    phenylalanine 4-monooxygenase activity GO:0004505 ISO
    amino acid binding GO:0016597 IDA
    cofactor binding GO:0048037 IDA
    protein homodimerization activity GO:0042803 IDA
    iron ion binding GO:0005506 IDA
Biological Process
    L-phenylalanine catabolic process GO:0006559 IEA
    pteridine-containing compound metabolic process GO:0042558 IDA
    oxidation-reduction process GO:0055114 ISO
    tyrosine biosynthetic process GO:0006571 IDA
    protein hydroxylation GO:0018126 IDA
    tetrahydrobiopterin metabolic process GO:0046146 IDA
    L-phenylalanine metabolic process GO:0006558 IDA
Subcellular Localization
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Pah in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Pah
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pah is involved
No pathways found





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