Gene description for Pah
Gene name phenylalanine hydroxylase
Gene symbol Pah
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Pah
ExoCarta ExoCarta_24616
Vesiclepedia VP_24616
Entrez Gene 24616
 Pah identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Pah
Molecular Function
    phenylalanine 4-monooxygenase activity GO:0004505 IBA
    phenylalanine 4-monooxygenase activity GO:0004505 IDA
    phenylalanine 4-monooxygenase activity GO:0004505 IEA
    phenylalanine 4-monooxygenase activity GO:0004505 ISO
    iron ion binding GO:0005506 IDA
    iron ion binding GO:0005506 IEA
    amino acid binding GO:0016597 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    L-phenylalanine metabolic process GO:0006558 IDA
    L-phenylalanine catabolic process GO:0006559 IEA
    tyrosine biosynthetic process GO:0006571 IBA
    tyrosine biosynthetic process GO:0006571 IDA
    protein hydroxylation GO:0018126 IDA
    tyrosine biosynthetic process, by oxidation of phenylalanine GO:0019293 IDA
    tyrosine biosynthetic process, by oxidation of phenylalanine GO:0019293 IEA
 Experiment description of studies that identified Pah in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Pah
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pah is involved
No pathways found





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