Gene description for Fmo5
Gene name flavin containing monooxygenase 5
Gene symbol Fmo5
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Fmo5
ExoCarta ExoCarta_246248
Vesiclepedia VP_246248
Entrez Gene 246248
UniProt Q8K4C0  
 Fmo5 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Fmo5
Molecular Function
    aldehyde oxidase activity GO:0004031 IEA
    aldehyde oxidase activity GO:0004031 ISO
    aldehyde oxidase activity GO:0004031 ISS
    monooxygenase activity GO:0004497 ISO
    N,N-dimethylaniline monooxygenase activity GO:0004499 IBA
    N,N-dimethylaniline monooxygenase activity GO:0004499 IDA
    N,N-dimethylaniline monooxygenase activity GO:0004499 IEA
    NAD(P)H oxidase H2O2-forming activity GO:0016174 IEA
    hypotaurine monooxygenase activity GO:0047822 IEA
    flavin adenine dinucleotide binding GO:0050660 IEA
    NADP binding GO:0050661 IEA
    NADPH oxidase H202-forming activity GO:0106294 IEA
Biological Process
    lipid metabolic process GO:0006629 IEA
    xenobiotic metabolic process GO:0006805 IEA
    xenobiotic metabolic process GO:0006805 ISO
    xenobiotic metabolic process GO:0006805 ISS
    NADPH oxidation GO:0070995 IEA
    NADPH oxidation GO:0070995 ISO
    NADPH oxidation GO:0070995 ISS
    regulation of cholesterol metabolic process GO:0090181 IEA
    regulation of cholesterol metabolic process GO:0090181 ISO
    regulation of cholesterol metabolic process GO:0090181 ISS
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    endoplasmic reticulum membrane GO:0005789 IEA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Fmo5 in sEVs
1
Experiment ID 35
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|CD81|CD63
Enriched markers
✔
HSPA5
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Fmo5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fmo5 is involved
No pathways found





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