Gene description for Adipoq
Gene name adiponectin, C1Q and collagen domain containing
Gene symbol Adipoq
Other names/aliases Acdc
Acrp30
Species Rattus norvegicus
 Database cross references - Adipoq
ExoCarta ExoCarta_246253
Entrez Gene 246253
 Adipoq identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Adipoq
Molecular Function
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    receptor binding GO:0005102 ISS
    sialic acid binding GO:0033691 ISO
    hormone activity GO:0005179 ISO
Biological Process
    negative regulation of smooth muscle cell proliferation GO:0048662 ISS
    positive regulation of renal albumin absorption GO:2000534 ISS
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 ISS
    positive regulation of fatty acid metabolic process GO:0045923 ISS
    cellular response to cAMP GO:0071320 IDA
    positive regulation of protein kinase activity GO:0045860 IDA
    positive regulation of cholesterol efflux GO:0010875 ISS
    glucose metabolic process GO:0006006 ISS
    negative regulation of receptor binding GO:1900121 ISS
    detection of oxidative stress GO:0070994 ISS
    negative regulation of protein autophosphorylation GO:0031953 ISS
    negative regulation of platelet-derived growth factor receptor-alpha signaling pathway GO:2000584 ISS
    negative regulation of MAP kinase activity GO:0043407 ISS
    negative regulation of inflammatory response GO:0050728 ISS
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    response to activity GO:0014823 IEP
    response to nutrient levels GO:0031667 IEP
    brown fat cell differentiation GO:0050873 ISS
    negative regulation of granulocyte differentiation GO:0030853 ISS
    positive regulation of glycogen (starch) synthase activity GO:2000467 IDA
    cellular response to epinephrine stimulus GO:0071872 IDA
    negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 ISS
    low-density lipoprotein particle clearance GO:0034383 ISS
    response to drug GO:0042493 IEP
    response to linoleic acid GO:0070543 IEP
    membrane depolarization GO:0051899 IDA
    response to hypoxia GO:0001666 IEP
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISS
    negative regulation of macrophage derived foam cell differentiation GO:0010745 ISS
    positive regulation of interleukin-8 production GO:0032757 ISS
    positive regulation of protein phosphorylation GO:0001934 ISS
    response to glucocorticoid GO:0051384 IEP
    circadian rhythm GO:0007623 IEP
    adiponectin-activated signaling pathway GO:0033211 IDA
    negative regulation of cell migration GO:0030336 ISS
    regulation of glucose metabolic process GO:0010906 ISS
    positive regulation of glucose import GO:0046326 ISS
    negative regulation of smooth muscle cell migration GO:0014912 ISS
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 ISS
    positive regulation of protein kinase A signaling GO:0010739 ISS
    positive regulation of cAMP-dependent protein kinase activity GO:2000481 ISS
    negative regulation of tumor necrosis factor production GO:0032720 ISS
    negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS
    fatty acid oxidation GO:0019395 NAS
    response to sucrose GO:0009744 IEP
    response to tumor necrosis factor GO:0034612 ISS
    membrane hyperpolarization GO:0060081 IDA
    negative regulation of macrophage differentiation GO:0045650 ISS
    protein heterotrimerization GO:0070208 ISO
    fatty acid beta-oxidation GO:0006635 ISS
    cellular response to insulin stimulus GO:0032869 ISS
    negative regulation of heterotypic cell-cell adhesion GO:0034115 ISS
    positive regulation of myeloid cell apoptotic process GO:0033034 ISS
    cellular response to drug GO:0035690 ISS
    protein localization to plasma membrane GO:0072659 ISS
    negative regulation of intracellular protein transport GO:0090317 ISS
    response to glucose GO:0009749 ISS
    negative regulation of metanephric mesenchymal cell migration GO:2000590 ISS
    protein homooligomerization GO:0051260 ISS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    glucose homeostasis GO:0042593 ISS
    negative regulation of synaptic transmission GO:0050805 ISS
    negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 ISS
    positive regulation of signal transduction GO:0009967 ISS
    negative regulation of DNA biosynthetic process GO:2000279 ISS
    response to ethanol GO:0045471 IEP
    negative regulation of hormone secretion GO:0046888 IDA
    positive regulation of blood pressure GO:0045777 IDA
    negative regulation of phagocytosis GO:0050765 ISS
    positive regulation of cellular protein metabolic process GO:0032270 ISS
    positive regulation of monocyte chemotactic protein-1 production GO:0071639 ISS
    negative regulation of fat cell differentiation GO:0045599 ISS
    response to nutrient GO:0007584 IEP
    positive regulation of metanephric glomerular visceral epithelial cell development GO:2000478 ISS
    negative regulation of gluconeogenesis GO:0045721 ISS
    negative regulation of blood pressure GO:0045776 ISS
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISS
    cell surface GO:0009986 ISS
    collagen trimer GO:0005581 IEA
    endoplasmic reticulum GO:0005783 ISS
    cell periphery GO:0071944 ISS
    extracellular space GO:0005615 ISO
    protein complex GO:0043234 IDA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Adipoq in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Adipoq
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adipoq is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here