Gene description for Adipoq
Gene name adiponectin, C1Q and collagen domain containing
Gene symbol Adipoq
Other names/aliases Acdc
Acrp30
Species Rattus norvegicus
 Database cross references - Adipoq
ExoCarta ExoCarta_246253
Vesiclepedia VP_246253
Entrez Gene 246253
 Adipoq identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Adipoq
Molecular Function
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    receptor binding GO:0005102 ISS
    sialic acid binding GO:0033691 ISO
    hormone activity GO:0005179 ISO
Biological Process
    negative regulation of smooth muscle cell proliferation GO:0048662 ISS
    positive regulation of renal albumin absorption GO:2000534 ISS
    negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 ISS
    positive regulation of fatty acid metabolic process GO:0045923 ISS
    cellular response to cAMP GO:0071320 IDA
    positive regulation of protein kinase activity GO:0045860 IDA
    positive regulation of cholesterol efflux GO:0010875 ISS
    glucose metabolic process GO:0006006 ISS
    negative regulation of receptor binding GO:1900121 ISS
    detection of oxidative stress GO:0070994 ISS
    negative regulation of protein autophosphorylation GO:0031953 ISS
    negative regulation of platelet-derived growth factor receptor-alpha signaling pathway GO:2000584 ISS
    negative regulation of MAP kinase activity GO:0043407 ISS
    negative regulation of inflammatory response GO:0050728 ISS
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    response to activity GO:0014823 IEP
    response to nutrient levels GO:0031667 IEP
    brown fat cell differentiation GO:0050873 ISS
    negative regulation of granulocyte differentiation GO:0030853 ISS
    positive regulation of glycogen (starch) synthase activity GO:2000467 IDA
    cellular response to epinephrine stimulus GO:0071872 IDA
    negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 ISS
    low-density lipoprotein particle clearance GO:0034383 ISS
    response to drug GO:0042493 IEP
    response to linoleic acid GO:0070543 IEP
    membrane depolarization GO:0051899 IDA
    response to hypoxia GO:0001666 IEP
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 ISS
    negative regulation of macrophage derived foam cell differentiation GO:0010745 ISS
    positive regulation of interleukin-8 production GO:0032757 ISS
    positive regulation of protein phosphorylation GO:0001934 ISS
    response to glucocorticoid GO:0051384 IEP
    circadian rhythm GO:0007623 IEP
    adiponectin-activated signaling pathway GO:0033211 IDA
    negative regulation of cell migration GO:0030336 ISS
    regulation of glucose metabolic process GO:0010906 ISS
    positive regulation of glucose import GO:0046326 ISS
    negative regulation of smooth muscle cell migration GO:0014912 ISS
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 ISS
    positive regulation of protein kinase A signaling GO:0010739 ISS
    positive regulation of cAMP-dependent protein kinase activity GO:2000481 ISS
    negative regulation of tumor necrosis factor production GO:0032720 ISS
    negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS
    fatty acid oxidation GO:0019395 NAS
    response to sucrose GO:0009744 IEP
    response to tumor necrosis factor GO:0034612 ISS
    membrane hyperpolarization GO:0060081 IDA
    negative regulation of macrophage differentiation GO:0045650 ISS
    protein heterotrimerization GO:0070208 ISO
    fatty acid beta-oxidation GO:0006635 ISS
    cellular response to insulin stimulus GO:0032869 ISS
    negative regulation of heterotypic cell-cell adhesion GO:0034115 ISS
    positive regulation of myeloid cell apoptotic process GO:0033034 ISS
    cellular response to drug GO:0035690 ISS
    protein localization to plasma membrane GO:0072659 ISS
    negative regulation of intracellular protein transport GO:0090317 ISS
    response to glucose GO:0009749 ISS
    negative regulation of metanephric mesenchymal cell migration GO:2000590 ISS
    protein homooligomerization GO:0051260 ISS
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA
    glucose homeostasis GO:0042593 ISS
    negative regulation of synaptic transmission GO:0050805 ISS
    negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 ISS
    positive regulation of signal transduction GO:0009967 ISS
    negative regulation of DNA biosynthetic process GO:2000279 ISS
    response to ethanol GO:0045471 IEP
    negative regulation of hormone secretion GO:0046888 IDA
    positive regulation of blood pressure GO:0045777 IDA
    negative regulation of phagocytosis GO:0050765 ISS
    positive regulation of cellular protein metabolic process GO:0032270 ISS
    positive regulation of monocyte chemotactic protein-1 production GO:0071639 ISS
    negative regulation of fat cell differentiation GO:0045599 ISS
    response to nutrient GO:0007584 IEP
    positive regulation of metanephric glomerular visceral epithelial cell development GO:2000478 ISS
    negative regulation of gluconeogenesis GO:0045721 ISS
    negative regulation of blood pressure GO:0045776 ISS
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISS
    cell surface GO:0009986 ISS
    collagen trimer GO:0005581 IEA
    endoplasmic reticulum GO:0005783 ISS
    cell periphery GO:0071944 ISS
    extracellular space GO:0005615 ISO
    protein complex GO:0043234 IDA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Adipoq in exosomes
1
Experiment ID 225
MISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Adipoq
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adipoq is involved
No pathways found





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