Gene description for Serbp1
Gene name Serpine1 mRNA binding protein 1
Gene symbol Serbp1
Other names/aliases Pai-Rbp1
Pairbp1
Rda288
Species Rattus norvegicus
 Database cross references - Serbp1
ExoCarta ExoCarta_246303
Vesiclepedia VP_246303
Entrez Gene 246303
UniProt Q6AXS5  
 Serbp1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Serbp1
Molecular Function
    RNA binding GO:0003723 IEA
    RNA binding GO:0003723 ISO
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 IEA
    mRNA 3'-UTR binding GO:0003730 ISO
    mRNA 3'-UTR binding GO:0003730 ISS
    translation repressor activity GO:0030371 IEA
    translation repressor activity GO:0030371 ISO
    translation repressor activity GO:0030371 ISS
    SUMO binding GO:0032183 IEA
    SUMO binding GO:0032183 ISO
    SUMO binding GO:0032183 ISS
    ribosome binding GO:0043022 IEA
    ribosome binding GO:0043022 ISO
    ribosome binding GO:0043022 ISS
    translation elongation factor binding GO:0061770 IEA
    translation elongation factor binding GO:0061770 ISO
Biological Process
    regulation of translation GO:0006417 IEA
    negative regulation of translation GO:0017148 ISO
    negative regulation of translation GO:0017148 ISS
    PML body organization GO:0030578 IEA
    PML body organization GO:0030578 ISO
    PML body organization GO:0030578 ISS
    regulation of apoptotic process GO:0042981 IDA
    ribosome hibernation GO:0141014 IEA
    ribosome hibernation GO:0141014 ISO
    ribosome hibernation GO:0141014 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IEA
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified Serbp1 in sEVs
1
Experiment ID 97
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Serbp1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Serbp1 is involved
No pathways found





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