Gene description for Pmp22
Gene name peripheral myelin protein 22
Gene symbol Pmp22
Other names/aliases Gas-3
Species Rattus norvegicus
 Database cross references - Pmp22
ExoCarta ExoCarta_24660
Entrez Gene 24660
UniProt P25094  
 Pmp22 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Pmp22
Biological Process
    negative regulation of neuron projection development GO:0010977 IDA
    myelination GO:0042552 IMP
    cell cycle arrest GO:0007050 IEA
    myelin assembly GO:0032288 ISO
    cell differentiation GO:0030154 IDA
    negative regulation of cell proliferation GO:0008285 IMP
    peripheral nervous system development GO:0007422 IC
    cell death GO:0008219 ISO
    bleb assembly GO:0032060 ISO
Subcellular Localization
    compact myelin GO:0043218 IDA
    plasma membrane GO:0005886 ISO
    bicellular tight junction GO:0005923 IDA
    integral component of membrane GO:0016021 IDA
 Experiment description of studies that identified Pmp22 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Pmp22
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pmp22 is involved
No pathways found





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