Gene description for Pmp22
Gene name peripheral myelin protein 22
Gene symbol Pmp22
Other names/aliases Gas-3
Species Rattus norvegicus
 Database cross references - Pmp22
ExoCarta ExoCarta_24660
Vesiclepedia VP_24660
Entrez Gene 24660
UniProt P25094  
 Pmp22 identified in sEVs derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Pmp22
Molecular Function
    cytoskeletal motor activity GO:0003774 ISO
Biological Process
    autophagy GO:0006914 ISO
    apoptotic process GO:0006915 ISO
    immune response GO:0006955 ISO
    cell adhesion GO:0007155 ISO
    peripheral nervous system development GO:0007422 IC
    peripheral nervous system development GO:0007422 ISO
    mating GO:0007618 ISO
    adult walking behavior GO:0007628 ISO
    cholesterol metabolic process GO:0008203 ISO
    negative regulation of cell population proliferation GO:0008285 IDA
    negative regulation of cell population proliferation GO:0008285 IMP
    adult locomotory behavior GO:0008344 ISO
    response to bacterium GO:0009617 ISO
    regulation of gene expression GO:0010468 ISO
    proteasomal protein catabolic process GO:0010498 ISO
    regulation of Schwann cell proliferation GO:0010624 ISO
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of gene expression GO:0010629 ISO
    fibroblast migration GO:0010761 ISO
    negative regulation of neuron projection development GO:0010977 IDA
    Schwann cell differentiation GO:0014037 ISO
    Schwann cell development GO:0014044 ISO
    transmission of nerve impulse GO:0019226 ISO
    neuronal action potential propagation GO:0019227 ISO
    neuronal action potential GO:0019228 ISO
    myelination in peripheral nervous system GO:0022011 ISO
    lamellipodium assembly GO:0030032 ISO
    actin cytoskeleton organization GO:0030036 ISO
    cell differentiation GO:0030154 IDA
    paranodal junction assembly GO:0030913 ISO
    membrane raft organization GO:0031579 ISO
    bleb assembly GO:0032060 ISO
    myelin assembly GO:0032288 IBA
    myelin assembly GO:0032288 ISO
    regulation of glial cell apoptotic process GO:0034350 ISO
    cellular response to heat GO:0034605 ISO
    cellular response to unfolded protein GO:0034620 ISO
    response to endoplasmic reticulum stress GO:0034976 ISO
    multicellular organism growth GO:0035264 ISO
    Schwann cell migration GO:0036135 ISO
    gliogenesis GO:0042063 ISO
    myelination GO:0042552 IDA
    myelination GO:0042552 IMP
    myelination GO:0042552 ISO
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 ISO
    neuronal ion channel clustering GO:0045161 ISO
    peripheral nervous system neuron axonogenesis GO:0048936 ISO
    regulation of inflammatory response GO:0050727 ISO
    neuromuscular process GO:0050905 ISO
    striated muscle cell differentiation GO:0051146 ISO
    regulation of cell cycle GO:0051726 IEA
    muscle cell development GO:0055001 ISO
    vestibular reflex GO:0060005 ISO
    axon development GO:0061564 ISO
    motor behavior GO:0061744 ISO
    aggresome assembly GO:0070842 ISO
    basement membrane organization GO:0071711 ISO
    regulation of protein serine/threonine kinase activity GO:0071900 ISO
    neuromuscular junction development, skeletal muscle fiber GO:0098529 ISO
    regulation of apoptotic signaling pathway GO:2001233 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    bicellular tight junction GO:0005923 IDA
    integrin complex GO:0008305 ISO
    cell surface GO:0009986 ISO
    membrane GO:0016020 ISO
    compact myelin GO:0043218 IDA
    compact myelin GO:0043218 ISO
    laminin complex GO:0043256 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
 Experiment description of studies that identified Pmp22 in sEVs
1
Experiment ID 92
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
MISEV standards
EM
Biophysical techniques
HSP70|GAPDH|CD9|CD151
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors "Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M."
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Pmp22
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pmp22 is involved
No pathways found





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