Gene description for Ptpn7
Gene name protein tyrosine phosphatase, non-receptor type 7
Gene symbol Ptpn7
Other names/aliases Heptp
Lcptp
Species Rattus norvegicus
 Database cross references - Ptpn7
ExoCarta ExoCarta_246781
Vesiclepedia VP_246781
Entrez Gene 246781
UniProt P49445  
 Ptpn7 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ptpn7
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    protein tyrosine phosphatase activity GO:0004725 IEA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 ISO
    signal transduction GO:0007165 IBA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISO
    microtubule cytoskeleton GO:0015630 ISO
    mitotic spindle GO:0072686 IEA
    mitotic spindle GO:0072686 ISO
 Experiment description of studies that identified Ptpn7 in sEVs
1
Experiment ID 95
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP90|HSC70|MHCI
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ptpn7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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