Gene description for Ptpn7
Gene name protein tyrosine phosphatase, non-receptor type 7
Gene symbol Ptpn7
Other names/aliases Heptp
Lcptp
Species Rattus norvegicus
 Database cross references - Ptpn7
ExoCarta ExoCarta_246781
Entrez Gene 246781
UniProt P49445  
 Ptpn7 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ptpn7
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IEA
Biological Process
    peptidyl-tyrosine dephosphorylation GO:0035335 IEA
    protein dephosphorylation GO:0006470 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
    cytoplasmic side of plasma membrane GO:0009898 ISO
    cytoskeleton GO:0005856 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Ptpn7 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ptpn7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ptpn7 is involved
No pathways found





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