Gene description for Prnp
Gene name	prion protein
Gene symbol	Prnp
Other names/aliases	PrP Prn
Species	Rattus norvegicus
Database cross references - Prnp
ExoCarta	ExoCarta_24686
Vesiclepedia	VP_24686
Entrez Gene	24686
UniProt	P13852
Prnp identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Prnp

Molecular Function     amyloid-beta binding GO:0001540 ISO     protease binding GO:0002020 ISO     copper ion binding GO:0005507 ISO     copper ion binding GO:0005507 ISS     lamin binding GO:0005521 IPI     glycosaminoglycan binding GO:0005539 ISO     microtubule binding GO:0008017 ISO     tubulin binding GO:0015631 ISO     aspartic-type endopeptidase inhibitor activity GO:0019828 ISO     type 5 metabotropic glutamate receptor binding GO:0031802 IPI     type 5 metabotropic glutamate receptor binding GO:0031802 ISO     type 8 metabotropic glutamate receptor binding GO:0031805 ISO     signaling receptor activity GO:0038023 ISO     identical protein binding GO:0042802 ISO     ATP-dependent protein binding GO:0043008 IPI     transmembrane transporter binding GO:0044325 IPI     protein-containing complex binding GO:0044877 ISO     metal ion binding GO:0046872 ISO     protein-folding chaperone binding GO:0051087 IPI     molecular adaptor activity GO:0060090 ISO     molecular function activator activity GO:0140677 IEA     molecular condensate scaffold activity GO:0140693 ISO     cupric ion binding GO:1903135 ISO     cuprous ion binding GO:1903136 ISO Biological Process     negative regulation of protein phosphorylation GO:0001933 ISO     response to oxidative stress GO:0006979 ISO     learning or memory GO:0007611 IMP     learning or memory GO:0007611 ISO     protein destabilization GO:0031648 ISO     activation of protein kinase activity GO:0032147 ISO     negative regulation of type II interferon production GO:0032689 ISO     negative regulation of interleukin-17 production GO:0032700 ISO     negative regulation of interleukin-2 production GO:0032703 ISO     regulation of protein localization GO:0032880 ISO     amyloid precursor protein metabolic process GO:0042982 ISO     negative regulation of apoptotic process GO:0043066 IMP     negative regulation of apoptotic process GO:0043066 ISO     negative regulation of catalytic activity GO:0043086 IDA     negative regulation of DNA-binding transcription factor activity GO:0043433 ISO     positive regulation of neuron apoptotic process GO:0043525 ISO     negative regulation of activated T cell proliferation GO:0046007 ISO     response to cadmium ion GO:0046686 IDA     response to copper ion GO:0046688 IDA     regulation of peptidyl-tyrosine phosphorylation GO:0050730 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     positive regulation of calcium-mediated signaling GO:0050850 ISO     negative regulation of T cell receptor signaling pathway GO:0050860 ISO     protein homooligomerization GO:0051260 IEA     negative regulation of calcineurin-NFAT signaling cascade GO:0070885 ISO     cellular response to copper ion GO:0071280 ISO     cellular response to xenobiotic stimulus GO:0071466 ISO     positive regulation of protein targeting to membrane GO:0090314 ISO     negative regulation of long-term synaptic potentiation GO:1900272 IDA     regulation of glutamate receptor signaling pathway GO:1900449 ISO     positive regulation of glutamate receptor signaling pathway GO:1900451 ISO     regulation of potassium ion transmembrane transport GO:1901379 ISO     negative regulation of amyloid-beta formation GO:1902430 ISO     negative regulation of dendritic spine maintenance GO:1902951 ISO     negative regulation of amyloid precursor protein catabolic process GO:1902992 ISO     positive regulation of protein localization to plasma membrane GO:1903078 IMP     positive regulation of protein localization to plasma membrane GO:1903078 ISO     response to amyloid-beta GO:1904645 ISO     cellular response to amyloid-beta GO:1904646 ISO     regulation of calcium ion import across plasma membrane GO:1905664 ISO     neuron projection maintenance GO:1990535 ISO Subcellular Localization     mitochondrial outer membrane GO:0005741 ISO     endoplasmic reticulum GO:0005783 ISO     Golgi apparatus GO:0005794 ISO     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     plasma membrane GO:0005886 ISO     cell surface GO:0009986 ISO     postsynaptic density GO:0014069 IDA     membrane GO:0016020 ISO     inclusion body GO:0016234 ISO     dendrite GO:0030425 ISO     dendrite GO:0030425 ISO     nuclear membrane GO:0031965 IEA     nuclear membrane GO:0031965 ISO     terminal bouton GO:0043195 ISO     intracellular membrane-bounded organelle GO:0043231 ISO     membrane raft GO:0045121 ISO     membrane raft GO:0045121 ISS     side of membrane GO:0098552 IEA