Gene description for Prss1
Gene name protease, serine, 1 (trypsin 1)
Gene symbol Prss1
Other names/aliases PTRYI
RATPTRYI
Try1
Species Rattus norvegicus
 Database cross references - Prss1
ExoCarta ExoCarta_24691
Entrez Gene 24691
UniProt P00762  
 Prss1 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Prss1
Molecular Function
    metal ion binding GO:0046872 IEA
    serine-type endopeptidase activity GO:0004252 IBA
Biological Process
    response to nutrient GO:0007584 IEP
    response to nicotine GO:0035094 IDA
    proteolysis GO:0006508 IBA
    response to organic substance GO:0010033 IEP
    digestion GO:0007586 TAS
    response to caffeine GO:0031000 IDA
Subcellular Localization
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 ISO
    blood microparticle GO:0072562 ISO
 Experiment description of studies that identified Prss1 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Prss1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prss1 is involved
PathwayEvidenceSource
Activation of Matrix Metalloproteinases IEA Reactome
Collagen degradation IEA Reactome





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