Gene description for Ptprc
Gene name protein tyrosine phosphatase, receptor type, C
Gene symbol Ptprc
Other names/aliases CD45
L-CA
Lca
RT7
T200
Species Rattus norvegicus
 Database cross references - Ptprc
ExoCarta ExoCarta_24699
Entrez Gene 24699
UniProt P04157  
 Ptprc identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for Ptprc
Molecular Function
    protein kinase binding GO:0019901 ISS
    transmembrane receptor protein tyrosine phosphatase activity GO:0005001 TAS
    protein tyrosine phosphatase activity GO:0004725 ISS
    protein kinase regulator activity GO:0019887 TAS
    heparin binding GO:0008201 ISO
    protein binding GO:0005515 IPI
    heparan sulfate proteoglycan binding GO:0043395 ISO
Biological Process
    bone marrow development GO:0048539 ISO
    negative regulation of cell adhesion involved in substrate-bound cell migration GO:0006933 ISO
    B cell proliferation GO:0042100 ISS
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 ISO
    regulation of B cell differentiation GO:0045577 ISO
    positive regulation of alpha-beta T cell proliferation GO:0046641 ISO
    regulation of humoral immune response mediated by circulating immunoglobulin GO:0002923 ISO
    cell cycle phase transition GO:0044770 ISO
    stem cell development GO:0048864 ISO
    negative thymic T cell selection GO:0045060 ISO
    positive regulation of T cell proliferation GO:0042102 ISS
    positive regulation of gamma-delta T cell differentiation GO:0045588 ISO
    dephosphorylation GO:0016311 ISS
    negative regulation of T cell mediated cytotoxicity GO:0001915 ISS
    positive regulation of hematopoietic stem cell migration GO:2000473 ISO
    positive regulation of B cell proliferation GO:0030890 ISO
    regulation of B cell receptor signaling pathway GO:0050855 ISO
    negative regulation of protein kinase activity GO:0006469 ISS
    T cell differentiation GO:0030217 ISS
    negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 ISO
    positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 ISO
    positive regulation of T cell mediated immunity GO:0002711 ISO
    B cell differentiation GO:0030183 ISO
    defense response to virus GO:0051607 ISS
    T cell proliferation GO:0042098 ISO
    release of sequestered calcium ion into cytosol GO:0051209 ISS
    regulation of extrinsic apoptotic signaling pathway GO:2001236 ISO
    protein dephosphorylation GO:0006470 TAS
    positive regulation of T cell differentiation GO:0045582 ISO
    B cell receptor signaling pathway GO:0050853 ISS
    response to gamma radiation GO:0010332 IDA
    negative regulation of cytokine-mediated signaling pathway GO:0001960 ISS
    T cell receptor signaling pathway GO:0050852 ISS
    positive regulation of MAPK cascade GO:0043410 ISO
    leukocyte cell-cell adhesion GO:0007159 ISO
    positive regulation of stem cell proliferation GO:2000648 ISO
    negative regulation of protein autophosphorylation GO:0031953 ISO
    positive regulation of T cell mediated cytotoxicity GO:0001916 ISO
    activation of MAPK activity GO:0000187 ISO
    positive regulation of isotype switching to IgG isotypes GO:0048304 ISO
    positive thymic T cell selection GO:0045059 ISO
    peptidyl-tyrosine dephosphorylation GO:0035335 TAS
    hematopoietic progenitor cell differentiation GO:0002244 ISO
    regulation of cell cycle GO:0051726 ISS
    heterotypic cell-cell adhesion GO:0034113 ISO
    positive regulation of antigen receptor-mediated signaling pathway GO:0050857 ISS
    immunoglobulin biosynthetic process GO:0002378 ISO
Subcellular Localization
    cytosol GO:0005829 ISO
    integral component of membrane GO:0016021 IDA
    extracellular exosome GO:0070062 ISO
    membrane GO:0016020 ISO
    membrane raft GO:0045121 IEA
    cell surface GO:0009986 ISO
    intracellular GO:0005622 ISS
    plasma membrane GO:0005886 ISO
    cytoplasmic side of plasma membrane GO:0009898 TAS
    cell periphery GO:0071944 ISO
    integral component of plasma membrane GO:0005887 IDA
    external side of plasma membrane GO:0009897 ISO
    focal adhesion GO:0005925 ISS
 Experiment description of studies that identified Ptprc in exosomes
1
Experiment ID 90
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSC70|HSP90|TSG101
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
3
Experiment ID 97
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP90|HSC70
EV Cytosolic markers
✔
MHCI
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ptprc
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ptprc is involved
No pathways found





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