Gene description for Ptprc
Gene name	protein tyrosine phosphatase, receptor type, C
Gene symbol	Ptprc
Other names/aliases	CD45 L-CA Lca RT7 T200
Species	Rattus norvegicus
Database cross references - Ptprc
ExoCarta	ExoCarta_24699
Vesiclepedia	VP_24699
Entrez Gene	24699
UniProt	P04157
Ptprc identified in sEVs derived from the following tissue/cell type
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Ptprc

Molecular Function     protein tyrosine phosphatase activity GO:0004725 IBA     protein tyrosine phosphatase activity GO:0004725 IEA     protein tyrosine phosphatase activity GO:0004725 IGI     protein tyrosine phosphatase activity GO:0004725 ISO     protein tyrosine phosphatase activity GO:0004725 ISS     non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA     transmembrane receptor protein tyrosine phosphatase activity GO:0005001 ISO     transmembrane receptor protein tyrosine phosphatase activity GO:0005001 TAS     signaling receptor binding GO:0005102 ISO     protein binding GO:0005515 IPI     heparin binding GO:0008201 ISO     protein kinase regulator activity GO:0019887 TAS     protein kinase binding GO:0019901 ISO     protein kinase binding GO:0019901 ISS     protein tyrosine kinase inhibitor activity GO:0030292 ISO     ankyrin binding GO:0030506 ISO     spectrin binding GO:0030507 ISO     protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA     heparan sulfate proteoglycan binding GO:0043395 ISO     histone H2AXY142 phosphatase activity GO:0140793 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 ISO     MAPK cascade GO:0000165 ISO     natural killer cell differentiation GO:0001779 ISO     negative regulation of T cell mediated cytotoxicity GO:0001915 ISO     negative regulation of T cell mediated cytotoxicity GO:0001915 ISS     positive regulation of T cell mediated cytotoxicity GO:0001916 ISO     negative regulation of cytokine-mediated signaling pathway GO:0001960 ISO     negative regulation of cytokine-mediated signaling pathway GO:0001960 ISS     hematopoietic progenitor cell differentiation GO:0002244 ISO     positive regulation of immunoglobulin production GO:0002639 ISO     positive regulation of T cell mediated immunity GO:0002711 ISO     regulation of humoral immune response mediated by circulating immunoglobulin GO:0002923 ISO     positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 ISO     chromatin remodeling GO:0006338 IEA     negative regulation of protein kinase activity GO:0006469 ISO     negative regulation of protein kinase activity GO:0006469 ISS     protein dephosphorylation GO:0006470 ISO     protein dephosphorylation GO:0006470 ISS     protein dephosphorylation GO:0006470 TAS     negative regulation of cell adhesion involved in substrate-bound cell migration GO:0006933 ISO     leukocyte cell-cell adhesion GO:0007159 ISO     signal transduction GO:0007165 IBA     response to gamma radiation GO:0010332 IDA     regulation of gene expression GO:0010468 IGI     regulation of gene expression GO:0010468 ISO     dephosphorylation GO:0016311 ISO     dephosphorylation GO:0016311 ISS     peptidyl-tyrosine phosphorylation GO:0018108 ISO     B cell differentiation GO:0030183 ISO     B cell differentiation GO:0030183 ISO     T cell differentiation GO:0030217 ISO     T cell differentiation GO:0030217 ISS     positive regulation of B cell proliferation GO:0030890 ISO     positive regulation of B cell proliferation GO:0030890 ISO     negative regulation of protein autophosphorylation GO:0031953 ISO     regulation of interleukin-8 production GO:0032677 ISO     negative regulation of interleukin-2 production GO:0032703 ISO     positive regulation of interleukin-2 production GO:0032743 ISO     positive regulation of tumor necrosis factor production GO:0032760 ISO     heterotypic cell-cell adhesion GO:0034113 ISO     T cell proliferation GO:0042098 ISO     B cell proliferation GO:0042100 ISO     B cell proliferation GO:0042100 ISO     B cell proliferation GO:0042100 ISS     positive regulation of T cell proliferation GO:0042102 ISO     positive regulation of T cell proliferation GO:0042102 ISS     gamma-delta T cell differentiation GO:0042492 ISO     positive regulation of MAP kinase activity GO:0043406 ISO     positive regulation of MAPK cascade GO:0043410 ISO     positive regulation of MAPK cascade GO:0043410 ISO     cell cycle phase transition GO:0044770 ISO     positive thymic T cell selection GO:0045059 ISO     negative thymic T cell selection GO:0045060 ISO     positive regulation of T cell differentiation GO:0045582 ISO     positive regulation of gamma-delta T cell differentiation GO:0045588 ISO     negative regulation of receptor signaling pathway via JAK-STAT GO:0046426 ISO     alpha-beta T cell proliferation GO:0046633 ISO     positive regulation of alpha-beta T cell proliferation GO:0046641 ISO     protein autophosphorylation GO:0046777 ISO     positive regulation of isotype switching to IgG isotypes GO:0048304 ISO     bone marrow development GO:0048539 ISO     stem cell development GO:0048864 ISO     positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO     negative regulation of peptidyl-tyrosine phosphorylation GO:0050732 ISO     regulation of phagocytosis GO:0050764 ISO     positive regulation of phagocytosis GO:0050766 ISO     positive regulation of calcium-mediated signaling GO:0050850 ISO     T cell receptor signaling pathway GO:0050852 IEA     T cell receptor signaling pathway GO:0050852 IGI     T cell receptor signaling pathway GO:0050852 ISO     T cell receptor signaling pathway GO:0050852 ISS     B cell receptor signaling pathway GO:0050853 ISO     B cell receptor signaling pathway GO:0050853 ISO     B cell receptor signaling pathway GO:0050853 ISS     regulation of T cell receptor signaling pathway GO:0050856 ISO     positive regulation of antigen receptor-mediated signaling pathway GO:0050857 ISO     positive regulation of antigen receptor-mediated signaling pathway GO:0050857 ISS     release of sequestered calcium ion into cytosol GO:0051209 ISO     release of sequestered calcium ion into cytosol GO:0051209 ISS     defense response to virus GO:0051607 ISO     defense response to virus GO:0051607 ISO     defense response to virus GO:0051607 ISS     regulation of cell cycle GO:0051726 ISO     regulation of cell cycle GO:0051726 ISS     positive regulation of Fc receptor mediated stimulatory signaling pathway GO:0060369 ISO     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISO     positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO     extrinsic apoptotic signaling pathway GO:0097191 ISO     negative regulation of interleukin-4-mediated signaling pathway GO:1902215 ISO     response to aldosterone GO:1904044 IEP     positive regulation of hematopoietic stem cell migration GO:2000473 ISO     positive regulation of stem cell proliferation GO:2000648 ISO     regulation of extrinsic apoptotic signaling pathway GO:2001236 ISO     positive regulation of extrinsic apoptotic signaling pathway GO:2001238 ISO Subcellular Localization     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 ISO     focal adhesion GO:0005925 ISO     focal adhesion GO:0005925 ISS     external side of plasma membrane GO:0009897 ISO     cytoplasmic side of plasma membrane GO:0009898 TAS     cell surface GO:0009986 IDA     cell surface GO:0009986 ISO     membrane GO:0016020 IEA     bleb GO:0032059 ISO     membrane raft GO:0045121 ISO     synapse GO:0045202 IEA     cell periphery GO:0071944 ISO     membrane microdomain GO:0098857 ISO