Gene description for RT1-M3-1
Gene name RT1 class Ib, locus M3, gene 1
Gene symbol RT1-M3-1
Other names/aliases 4B2/3.7
H2-M3
RT1-M3
RanoM3
RanoM301
RanoM302
Species Rattus norvegicus
 Database cross references - RT1-M3-1
ExoCarta ExoCarta_24747
Vesiclepedia VP_24747
Entrez Gene 24747
 RT1-M3-1 identified in sEVs derived from the following tissue/cell type
Reticulocytes 21828046    
Reticulocytes 21828046    
 Gene ontology annotations for RT1-M3-1
Molecular Function
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 ISO
    peptide antigen binding GO:0042605 IBA
    peptide antigen binding GO:0042605 ISO
    CD8 receptor binding GO:0042610 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
Biological Process
    negative regulation of T cell mediated cytotoxicity GO:0001915 ISO
    positive regulation of T cell mediated cytotoxicity GO:0001916 IBA
    positive regulation of T cell mediated cytotoxicity GO:0001916 ISO
    response to molecule of bacterial origin GO:0002237 ISO
    alpha-beta T cell activation involved in immune response GO:0002287 ISO
    peripheral B cell tolerance induction GO:0002451 ISO
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 IBA
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 ISO
    antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 ISO
    antigen processing and presentation of exogenous peptide antigen via MHC class Ib GO:0002477 ISO
    antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002481 ISO
    antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 IBA
    positive regulation of tolerance induction GO:0002645 ISO
    positive regulation of T cell tolerance induction GO:0002666 ISO
    positive regulation of natural killer cell cytokine production GO:0002729 ISO
    immune response-inhibiting cell surface receptor signaling pathway GO:0002767 ISO
    nitric oxide biosynthetic process GO:0006809 ISO
    immune response GO:0006955 IBA
    negative regulation of angiogenesis GO:0016525 ISO
    positive regulation of type II interferon production GO:0032729 ISO
    positive regulation of interleukin-12 production GO:0032735 ISO
    negative regulation of T cell proliferation GO:0042130 ISO
    protection from natural killer cell mediated cytotoxicity GO:0042270 ISO
    defense response to bacterium GO:0042742 ISO
    positive regulation of nitric oxide biosynthetic process GO:0045429 ISO
    positive regulation of regulatory T cell differentiation GO:0045591 ISO
    negative regulation of natural killer cell mediated cytotoxicity GO:0045953 ISO
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 ISO
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 ISO
    positive regulation of macrophage cytokine production GO:0060907 ISO
    protein homotrimerization GO:0070207 ISO
    negative regulation of G0 to G1 transition GO:0070317 ISO
    positive regulation of endothelial cell apoptotic process GO:2000353 ISO
    positive regulation of cellular senescence GO:2000774 ISO
    negative regulation of dendritic cell differentiation GO:2001199 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    early endosome GO:0005769 ISO
    plasma membrane GO:0005886 ISO
    external side of plasma membrane GO:0009897 IBA
    external side of plasma membrane GO:0009897 ISO
    MHC class Ib protein complex GO:0032398 ISO
    cis-Golgi network membrane GO:0033106 ISO
 Experiment description of studies that identified RT1-M3-1 in sEVs
1
Experiment ID 90
MISEV standards
EM
Biophysical techniques
HSC70|HSP90|TSG101|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E"
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 94
MISEV standards
EM
Biophysical techniques
TSG101|HSP90|HSC70|MHCI
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors "Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E."
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for RT1-M3-1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RT1-M3-1 is involved
No pathways found





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