Gene description for Sdc4
Gene name syndecan 4
Gene symbol Sdc4
Other names/aliases RATRYUDOCA
RYUDOCA
Species Rattus norvegicus
 Database cross references - Sdc4
ExoCarta ExoCarta_24771
Entrez Gene 24771
UniProt P34901  
 Sdc4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Sdc4
Molecular Function
    protein kinase C binding GO:0005080 IDA
    thrombospondin receptor activity GO:0070053 ISO
    fibronectin binding GO:0001968 IDA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of protein kinase activity GO:0045860 IMP
    cell-cell signaling GO:0007267 NAS
    cell migration GO:0016477 IBA
    cell adhesion GO:0007155 NAS
    signal transduction GO:0007165 IEA
    regulation of fibroblast migration GO:0010762 ISO
    positive regulation of extracellular exosome assembly GO:1903553 ISO
    wound healing GO:0042060 ISO
    positive regulation of focal adhesion assembly GO:0051894 IMP
    positive regulation of exosomal secretion GO:1903543 ISO
    positive regulation of stress fiber assembly GO:0051496 IMP
    neural tube closure GO:0001843 ISO
    inner ear receptor stereocilium organization GO:0060122 ISO
    ureteric bud development GO:0001657 IEP
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    integral component of membrane GO:0016021 IEA
    cell surface GO:0009986 ISO
    plasma membrane GO:0005886 TAS
    costamere GO:0043034 IDA
    membrane raft GO:0045121 IDA
    focal adhesion GO:0005925 IDA
 Experiment description of studies that identified Sdc4 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Sdc4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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