Gene description for Sdc4
Gene name syndecan 4
Gene symbol Sdc4
Other names/aliases RATRYUDOCA
RYUDOCA
Species Rattus norvegicus
 Database cross references - Sdc4
ExoCarta ExoCarta_24771
Vesiclepedia VP_24771
Entrez Gene 24771
UniProt P34901  
 Sdc4 identified in sEVs derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Sdc4
Molecular Function
    fibronectin binding GO:0001968 IDA
    protein kinase C binding GO:0005080 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    identical protein binding GO:0042802 ISO
    thrombospondin receptor activity GO:0070053 ISO
Biological Process
    ureteric bud development GO:0001657 IEP
    neural tube closure GO:0001843 ISO
    cell adhesion GO:0007155 NAS
    cell-cell signaling GO:0007267 NAS
    regulation of fibroblast migration GO:0010762 ISO
    cell migration GO:0016477 IBA
    wound healing GO:0042060 ISO
    negative regulation of T cell proliferation GO:0042130 ISO
    positive regulation of protein kinase activity GO:0045860 IMP
    positive regulation of stress fiber assembly GO:0051496 IMP
    positive regulation of focal adhesion assembly GO:0051894 IMP
    inner ear receptor cell stereocilium organization GO:0060122 ISO
    positive regulation of exosomal secretion GO:1903543 ISO
    positive regulation of extracellular exosome assembly GO:1903553 ISO
    regulation of aortic smooth muscle cell differentiation GO:1904829 IDA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 TAS
    focal adhesion GO:0005925 IDA
    cell surface GO:0009986 IBA
    cell surface GO:0009986 IDA
    cell surface GO:0009986 ISO
    costamere GO:0043034 IDA
 Experiment description of studies that identified Sdc4 in sEVs
1
Experiment ID 35
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|CD81|CD63
Enriched markers
HSPA5
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors "Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM"
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Sdc4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mib1  
Affinity Capture-MS Rattus norvegicus
Affinity Capture-MS Rattus norvegicus
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