Gene description for Slc10a1
Gene name solute carrier family 10 (sodium/bile acid cotransporter), member 1
Gene symbol Slc10a1
Other names/aliases Ntcp
Ntcp1
SBACT
Species Rattus norvegicus
 Database cross references - Slc10a1
ExoCarta ExoCarta_24777
Entrez Gene 24777
UniProt P26435  
 Slc10a1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Slc10a1
Molecular Function
    bile acid transmembrane transporter activity GO:0015125 IDA
    bile acid:sodium symporter activity GO:0008508 TAS
Biological Process
    transmembrane transport GO:0055085 IEA
    sodium ion transport GO:0006814 IEA
    bile acid and bile salt transport GO:0015721 IDA
Subcellular Localization
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 IDA
    integral component of plasma membrane GO:0005887 IBA
 Experiment description of studies that identified Slc10a1 in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Slc10a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc10a1 is involved
PathwayEvidenceSource
Recycling of bile acids and salts IEA Reactome





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