Gene description for Slc2a1
Gene name solute carrier family 2 (facilitated glucose transporter), member 1
Gene symbol Slc2a1
Other names/aliases GLUTB
GTG1
Glut1
Gtg3
RATGTG1
Species Rattus norvegicus
 Database cross references - Slc2a1
ExoCarta ExoCarta_24778
Entrez Gene 24778
UniProt P11167  
 Slc2a1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
Reticulocytes 21828046    
 Gene ontology annotations for Slc2a1
Molecular Function
    sugar:proton symporter activity GO:0005351 TAS
    identical protein binding GO:0042802 ISO
    D-glucose transmembrane transporter activity GO:0055056 ISO
    glucose transmembrane transporter activity GO:0005355 ISO
    kinase binding GO:0019900 IPI
    protein self-association GO:0043621 ISS
    protein binding GO:0005515 IPI
    xenobiotic transporter activity GO:0042910 IDA
    dehydroascorbic acid transporter activity GO:0033300 ISO
Biological Process
    dehydroascorbic acid transport GO:0070837 ISO
    hexose transmembrane transport GO:0035428 ISO
    xenobiotic transport GO:0042908 IDA
    glucose import GO:0046323 IBA
    response to osmotic stress GO:0006970 IEP
    cellular response to glucose starvation GO:0042149 ISO
    glucose transport GO:0015758 TAS
    proton transport GO:0015992 TAS
    protein complex assembly GO:0006461 ISS
Subcellular Localization
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    integral component of plasma membrane GO:0005887 ISS
    membrane GO:0016020 ISO
    basolateral plasma membrane GO:0016323 ISO
    caveola GO:0005901 IDA
    midbody GO:0030496 ISO
    cortical actin cytoskeleton GO:0030864 ISS
    membrane raft GO:0045121 ISO
    cell-cell junction GO:0005911 IDA
    integral component of membrane GO:0016021 TAS
    intracellular GO:0005622 ISO
    vesicle GO:0031982 ISO
    blood microparticle GO:0072562 ISO
    melanosome GO:0042470 IEA
    female pronucleus GO:0001939 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Slc2a1 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
2
Experiment ID 97
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D4 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc2a1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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